| Literature DB >> 6547167 |
M F da Cunha, M L Meistrich, L M Fuller, J H Cundiff, F B Hagemeister, W S Velasquez, P McLaughlin, S A Riggs, F F Cabanillas, P G Salvador.
Abstract
The sperm production of 25 patients with Hodgkin's disease treated with mechlorethamine, vincristine, procarbazine, and prednisone (MOPP) chemotherapy was studied retrospectively. All but two patients also received radiotherapy treatment to pelvic and/or non-pelvic fields. Sperm counts were obtained from patients treated either with three or fewer (MOPP-2 group) or with five or more (MOPP-6 group) chemotherapy cycles. Recovery of spermatogenesis following treatment-induced azoospermia was significantly higher among the MOPP-2 patients (Mann-Whitney rank sum test, p = 0.001). Patients in this group who did not receive pelvic irradiation appeared to have greater recovery rates (p = 0.06). The results suggest that three cycles of MOPP chemotherapy represent a maximum exposure compatible with the recovery of spermatogenesis.Entities:
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Year: 1984 PMID： 6547167 DOI： 10.1200/JCO.1984.2.6.571
Source DB: PubMed Journal: J Clin Oncol ISSN： 0732-183X Impact factor: 44.544