Literature DB >> 6547163

Absorption and circular dichroism studies of a gold (I)-DNA complex.

C E Blank, J C Dabrowiak.   

Abstract

The DNA binding properties of the Au(I)-containing antiarthritic drug Ridaura and related Au(I) complexes have been investigated. Absorption and circular dichroism spectroscopy show that if the gold ion possesses an easily displaced ligand, e.g., Cl- or Br-, Au(I) is capable of interacting, in a nondenaturing fashion, with calf thymus DNA. Absorption studies with the four DNA nucleosides suggest that guanine and cytosine bases are important in the Au(I)DNA interaction.

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Year:  1984        PMID： 6547163     DOI： 10.1016/0162-0134(84)85036-9

Source DB:  PubMed          Journal:  J Inorg Biochem        ISSN： 0162-0134            Impact factor:   4.155


  4 in total

1.  Titanocene-phosphine derivatives as precursors to cytotoxic heterometallic TiAu2 and TiM (M = Pd, Pt) compounds. Studies of their interactions with DNA.

Authors:  Jose F González-Pantoja; Michael Stern; Andrzej A Jarzecki; Eva Royo; Elisa Robles-Escajeda; Armando Varela-Ramírez; Renato J Aguilera; María Contel
Journal:  Inorg Chem       Date:  2011-09-29       Impact factor: 5.165

2.  Cytotoxic hydrophilic iminophosphorane coordination compounds of d⁸ metals. Studies of their interactions with DNA and HSA.

Authors:  Monica Carreira; Rubén Calvo-Sanjuán; Mercedes Sanaú; Xiangbo Zhao; Richard S Magliozzo; Isabel Marzo; María Contel
Journal:  J Inorg Biochem       Date:  2012-07-06       Impact factor: 4.155

3.  Gold(I) analogues of a platinum-acridine antitumor agent are only moderately cytotoxic but show potent activity against Mycobacterium tuberculosis.

Authors:  Lauren C Eiter; Nathan W Hall; Cynthia S Day; Gilda Saluta; Gregory L Kucera; Ulrich Bierbach
Journal:  J Med Chem       Date:  2009-11-12       Impact factor: 7.446

4.  DNA hybridization sensor based on aurothiomalate electroactive label on glassy carbon electrodes.

Authors:  Alfredo de la Escosura-Muñiz; María Begoña González-García; Agustín Costa-García
Journal:  Biosens Bioelectron       Date:  2006-06-09       Impact factor: 10.618
  4 in total

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