Literature DB >> 6547132

A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics.

B Cavalleri, H Pagani, G Volpe, E Selva, F Parenti.   

Abstract

Actinoplanes sp. ATCC 33076 is a new strain that was found to produce an antibiotic, designated A-16686, which is a complex of three closely-related polypeptides containing chlorinated phenyl moieties and D-mannose. Both the complex and the single fractions possess a good activity against Gram-positive bacteria. A-16686 specifically inhibits the synthesis of the bacterial cell wall.

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Year:  1984        PMID： 6547132     DOI： 10.7164/antibiotics.37.309

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  24 in total

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Review 2.  Alzheimer disease.

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3.  A crystal structure of a dimer of the antibiotic ramoplanin illustrates membrane positioning and a potential Lipid II docking interface.

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4.  Additional congeners of the macrolide neaumycin: structure revision and biological activity.

Authors:  Matteo Simone; Sonia I Maffioli; Arianna Tocchetti; Stefano Tretter; Monica Cattaneo; Ida Biunno; Eleonora Gaspari; Stefano Donadio
Journal:  J Antibiot (Tokyo)       Date:  2015-01-14       Impact factor: 2.649

5.  Enduracidin analogues with altered halogenation patterns produced by genetically engineered strains of Streptomyces fungicidicus.

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Journal:  J Nat Prod       Date:  2010-04-23       Impact factor: 4.050

6.  In vitro evaluation of ramoplanin (MDL 62198, A 16686)

Authors:  S Dixson; W Brumfitt; J M Hamilton-Miller
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1988-12       Impact factor: 3.267

7.  Complexation of peptidoglycan intermediates by the lipoglycodepsipeptide antibiotic ramoplanin: minimal structural requirements for intermolecular complexation and fibril formation.

Authors:  Predrag Cudic; James K Kranz; Douglas C Behenna; Ryan G Kruger; Hellina Tadesse; A Joshua Wand; Yuri I Veklich; John W Weisel; Dewey G McCafferty
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

8.  Inhibition of peptidoglycan biosynthesis by ramoplanin.

Authors:  E A Somner; P E Reynolds
Journal:  Antimicrob Agents Chemother       Date:  1990-03       Impact factor: 5.191

9.  Design, Synthesis, and Study of Lactam and Ring-Expanded Analogues of Teixobactin.

Authors:  Hyunjun Yang; Arthur V Pishenko; Xingyue Li; James S Nowick
Journal:  J Org Chem       Date:  2019-12-09       Impact factor: 4.354

10.  Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue.

Authors:  Joonwoo Nam; Dongwoo Shin; Yosup Rew; Dale L Boger
Journal:  J Am Chem Soc       Date:  2007-06-26       Impact factor: 15.419
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