| Literature DB >> 6546971 |
B Barlogie, L Smith, R Alexanian.
Abstract
Twenty-nine patients with advanced refractory multiple myeloma were treated with intermittent high-dose dexamethasone in combination with four-day infusions of vincristine and doxorubicin. Rapid and marked tumor-mass reduction (greater than 75 per cent) was noted in 14 of 20 patients whose disease was resistant to alkylating agents and in 3 of 9 patients with additional resistance to doxorubicin--a result far superior to those in previous trials with similar patients. In responsive patients, remissions were of excellent quality, and survival was significantly longer than in unresponsive patients.Entities:
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Year: 1984 PMID： 6546971 DOI： 10.1056/NEJM198405243102104
Source DB: PubMed Journal: N Engl J Med ISSN： 0028-4793 Impact factor: 91.245