Enhanced cell mediated immunity in mice after cisplatin treatment.

Tumor regression in mice after cisplatin treatment and the role of cell mediated immunity were studied through Winn assay (in vivo) and capillary cell migration inhibition assay (in vitro). The immunization of mice with the platinum complex results in specific enhancement of host cellular immune system by stimulating splenocytes and peritoneal exudate cells against the specific tumor antigens.