Literature DB >> 6542968

Drug resistance induction and cross-resistance studies with Pt-complexes.

M Hrubisko, E Balázová, V Ujházy.   

Abstract

In vitro drug resistance was induced against cis-diamminedichloroplatinum(II) (cis-DDP), 1,2-diaminocyclohexaneplatinum-(II)citrate (PEX) and 1,2-diaminocyclohexaneplatinum(II)glucarate (PTU) in L1210 leukemia cell line. Using the resistant sublines cross-resistance was found between cis-DDP and cis-diamminecyclobutane-1,1-dicarboxylatoplatinum(II) (CBDCA) and between the three 1,2-diaminocyclohexane (DACH) derivatives tested. No (or low degree) cross-resistance was found between cis-DDP and DACH derivatives.

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Year:  1984        PMID： 6542968

Source DB:  PubMed          Journal:  Neoplasma        ISSN： 0028-2685            Impact factor:   2.575


  3 in total

1.  Absolute and relative activities of platinum-complexes on human tumors as evaluated by an antimetabolic in vitro assay.

Authors:  M G Daidone; R Silvestrini; N Zaffaroni; E Grignolio; F Landoni
Journal:  Invest New Drugs       Date:  1987       Impact factor: 3.850

Review 2.  Resistance to cisplatin and analogues: mechanisms and potential clinical implications.

Authors:  A de Graeff; R J Slebos; S Rodenhuis
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

3.  In vitro evaluation of platinum, titanium and ruthenium metal complexes in cisplatin-sensitive and -resistant rat ovarian tumors.

Authors:  S Frühauf; W J Zeller
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333
  3 in total

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