Literature DB >> 6542469

7 S collagen: a method for the measurement of serum concentrations in man.

B Högemann, B Voss, G Pott, J Rauterberg, U Gerlach.   

Abstract

A radioimmunoassay was developed for the detection of 7 S collagen, a basement membrane component derived from type IV collagen, in sera of patients. Two forms of 7 S collagen were isolated by limited collagenase digestion of type IV collagen from bovine placenta. Antisera against both forms were raised in rabbits. The antigens were labeled by conjugation with the Bolton Hunter reagent or by the Chloramine T method. Free and bound antigen were separated using a second antibody directed against rabbit-IgG. Serum concentrations of 7 S collagen ranged from 5-14 micrograms/l. Serum levels of 7 S collagen were increased in diabetic patients as compared to normal subjects.

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Year:  1984        PMID： 6542469     DOI： 10.1016/0009-8981(84)90254-7

Source DB:  PubMed          Journal:  Clin Chim Acta        ISSN： 0009-8981            Impact factor:   3.786


  4 in total

Review 1.  Hepatic fibrosis--current concepts of pathogenesis and therapy.

Authors:  B Högemann; W Domschke
Journal:  Gastroenterol Jpn       Date:  1993-08

2.  Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin.

Authors:  Yuki Hamano; Michael Zeisberg; Hikaru Sugimoto; Julie C Lively; Yohei Maeshima; Changqing Yang; Richard O Hynes; Zena Werb; Akulapalli Sudhakar; Raghu Kalluri
Journal:  Cancer Cell       Date:  2003-06       Impact factor: 31.743

3.  Concentrations of 7S collagen and laminin P1 in sera of patients with diabetes mellitus.

Authors:  B Högemann; B Voss; F J Altenwerth; M Schneider; J Rauterberg; U Gerlach
Journal:  Klin Wochenschr       Date:  1986-04-15

4.  MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays.

Authors:  Jannie Marie Sand; Lise Larsen; Cory Hogaboam; Fernando Martinez; Meilan Han; Martin Røssel Larsen; Arkadiusz Nawrocki; Qinlong Zheng; Morten Asser Karsdal; Diana Julie Leeming
Journal:  PLoS One       Date:  2013-12-23       Impact factor: 3.240
  4 in total

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