Literature DB >> 6542129

Ultrastructure of paired helical filaments of Alzheimer's neurofibrillary tangle.

H M Wisniewski, P A Merz, K Iqbal.   

Abstract

Isolated paired helical filaments (PHF) of Alzheimer's disease and senile dementia of the Alzheimer type (AD/SDAT) were studied by negative stain techniques and electron microscopy (EM). The helical structure of the PHF was confirmed by tilt analysis of negatively stained isolated PHF. A substructure of four protofilaments, each 3-5 nm in diameter, was also observed. A comparison of PHF substructure, neurofilaments and microtubules, revealed no similarity among the three structures.

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Year:  1984        PMID： 6542129     DOI： 10.1097/00005072-198411000-00008

Source DB:  PubMed          Journal:  J Neuropathol Exp Neurol        ISSN： 0022-3069            Impact factor:   3.685


  31 in total

1.  Immune electron microscopic characterization of monoclonal antibodies to Alzheimer neurofibrillary tangles.

Authors:  M A Wrzolek; P A Merz; R Kascsak; I Grundke-Iqbal; K Iqbal; R Rubenstein; M Tonna-DeMasi; N L Goller; P Mehta; H M Wisniewski
Journal:  Am J Pathol       Date:  1992-08       Impact factor: 4.307

2.  Ultrastructural and immunohistochemical study of degenerate neurite-bearing ghost tangles.

Authors:  K Ikeda; C Haga; S Oyanagi; S Iritani; K Kosaka
Journal:  J Neurol       Date:  1992-04       Impact factor: 4.849

Review 3.  Ubiquitination and abnormal phosphorylation of paired helical filaments in Alzheimer's disease.

Authors:  K Iqbal; I Grundke-Iqbal
Journal:  Mol Neurobiol       Date:  1991       Impact factor: 5.590

4.  Aluminum neurotoxicity in mammals.

Authors:  H M Wisniewski; R C Moretz; J A Sturman; G Y Wen; J W Shek
Journal:  Environ Geochem Health       Date:  1990-03       Impact factor: 4.609

5.  Ultrastructural evidence that insoluble microtubules are components of the neurofibrillary tangle.

Authors:  M A Pappolla; J Alzofon; J McMahon; T J Theodoropoulos
Journal:  Eur Arch Psychiatry Neurol Sci       Date:  1990

6.  Intracellular neurofibrillary tangle-like aggregations. A constantly present amyloid alteration in the aging choroid plexus.

Authors:  L Eriksson; P Westermark
Journal:  Am J Pathol       Date:  1986-10       Impact factor: 4.307

7.  Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity.

Authors:  Alejandra del C Alonso; Bin Li; Inge Grundke-Iqbal; Khalid Iqbal
Journal:  Proc Natl Acad Sci U S A       Date:  2006-05-30       Impact factor: 11.205

8.  Solubility of neurofibrillary tangles and ultrastructure of paired helical filaments in sodium dodecylsulphate.

Authors:  S Hussey; P H Gibson; R A Elton; C M Yates; J E Christie; P A Eagles; A Gordon
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

9.  Twisted tubulofilaments of inclusion body myositis muscle resemble paired helical filaments of Alzheimer brain and contain hyperphosphorylated tau.

Authors:  V Askanas; W K Engel; M Bilak; R B Alvarez; D J Selkoe
Journal:  Am J Pathol       Date:  1994-01       Impact factor: 4.307

10.  Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease.

Authors:  A C Alonso; T Zaidi; I Grundke-Iqbal; K Iqbal
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205
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