Literature DB >> 6541999

Genotoxicity of glycol ethers.

D B McGregor.   

Abstract

The genetic toxicology of glycol ethers is reviewed. Ethylene glycol monomethyl ether (EGME) and diglyme have been more extensively studied than other members of this series. Most results indicate a lack of genotoxic potential, but certain tests have yielded positive responses with certain compounds. Ethylene glycol monoethyl ether (EGEE) induced sister chromatid exchanges and chromosomal aberrations in cultured cells. Both EGME and diglyme induced mouse sperm head morphological changes, male rat weak dominant lethal mutations and marked, but reversible, loss of male rat fertility.

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Year:  1984        PMID： 6541999      PMCID： PMC1568302          DOI： 10.1289/ehp.845797

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  18 in total

1.  The destructive effect of cadmium ion on testicular tissue and its prevention by zinc.

Authors:  J PARIZEK
Journal:  J Endocrinol       Date:  1957-04       Impact factor: 4.286

2.  The metabolism of isopropyl oxitol in rat and dog.

Authors:  D H Hutson; B A Pickering
Journal:  Xenobiotica       Date:  1971-03       Impact factor: 1.908

3.  The relationship between early deaths and implants in control and mutagen-treated CD-1 mice in dominant lethal assays.

Authors:  D Anderson; D B McGregor; T M Weight
Journal:  Mutat Res       Date:  1981-04       Impact factor: 2.433

4.  Compatibility of organic solvents with the Salmonella/microsome test.

Authors:  D Maron; J Katzenellenbogen; B N Ames
Journal:  Mutat Res       Date:  1981-04       Impact factor: 2.433

5.  Testicular toxicity of ethylene glycol monomethyl and monoethyl ethers in the rat.

Authors:  P M Foster; D M Creasy; J R Foster; L V Thomas; M W Cook; S D Gangolli
Journal:  Toxicol Appl Pharmacol       Date:  1983-07       Impact factor: 4.219

6.  Genetic effects of 2-methoxyethanol and bis(2-methoxyethyl)ether.

Authors:  D B McGregor; M J Willins; P McDonald; M Holmström; D McDonald; R W Niemeier
Journal:  Toxicol Appl Pharmacol       Date:  1983-09-15       Impact factor: 4.219

7.  The use of organic solvents in mutagenicity testing.

Authors:  A Abbondandolo; S Bonatti; C Corsi; G Corti; R Fiorio; C Leporini; A Mazzaccaro; R Nieri; R Barale; N Loprieno
Journal:  Mutat Res       Date:  1980-10       Impact factor: 2.433

8.  Comparative metabolism and disposition of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in male rats.

Authors:  R R Miller; E A Hermann; P W Langvardt; M J McKenna; B A Schwetz
Journal:  Toxicol Appl Pharmacol       Date:  1983-02       Impact factor: 4.219

9.  [Testicular atrophy of mice induced by ethylene glycol mono alkyl ethers (author's transl)].

Authors:  K Nagano; E Nakayama; M Koyano; H Oobayashi; H Adachi; T Yamada
Journal:  Sangyo Igaku       Date:  1979-01

10.  The effect of solvents on drug metabolism in vitro.

Authors:  J C Kawalek; A W Andrews
Journal:  Drug Metab Dispos       Date:  1980 Nov-Dec       Impact factor: 3.922
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  5 in total

1.  Semen quality in workers exposed to 2-ethoxyethanol.

Authors:  J M Ratcliffe; S M Schrader; D E Clapp; W E Halperin; T W Turner; R W Hornung
Journal:  Br J Ind Med       Date:  1989-06

2.  Reproductive assessment by continuous breeding: evolving study design and summaries of ninety studies.

Authors:  R E Chapin; R A Sloane
Journal:  Environ Health Perspect       Date:  1997-02       Impact factor: 9.031

3.  Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers.

Authors:  B Söhnlein; S Letzel; D Weltle; H W Rüdiger; J Angerer
Journal:  Int Arch Occup Environ Health       Date:  1993       Impact factor: 3.015

4.  Glymes as Versatile Solvents for Chemical Reactions and Processes: from the Laboratory to Industry.

Authors:  Shaokun Tang; Hua Zhao
Journal:  RSC Adv       Date:  2014       Impact factor: 3.361

5.  Effects of β-glucan polysaccharide revealed by the dominant lethal assay and micronucleus assays, and reproductive performance of male mice exposed to cyclophosphamide.

Authors:  Rodrigo Juliano Oliveira; João Renato Pesarini; Maria José Sparça Salles; Tatiane Yumi Nakamura Kanno; Ana Carolina Dos Santos Lourenço; Véssia da Silva Leite; Ariane Fernanda da Silva; Hevenilton José Matiazi; Lúcia Regina Ribeiro; Mário Sérgio Mantovani
Journal:  Genet Mol Biol       Date:  2013-02-28       Impact factor: 1.771
  5 in total

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