Literature DB >> 6541517

Effect of pertussis toxin on normorphine-dependence and on acute inhibitory effects of normorphine and clonidine in guinea-pig isolated ileum.

J F Tucker.   

Abstract

In guinea-pig isolated ileum from animals pretreated with Pertussis toxin, the acute inhibitory effects of normorphine and clonidine on electrically induced contractions were markedly attenuated whilst responses to acetylcholine and electrical stimulation were unaltered. Pertussis toxin treatment also reduced naloxone-precipitated withdrawal contractures in normorphine-dependent tissues. These results suggest that the acute and chronic effects of normorphine are mediated by the same mechanism, namely that of adenylate cyclase inhibition.

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Year:  1984        PMID： 6541517      PMCID： PMC1987113          DOI： 10.1111/j.1476-5381.1984.tb16491.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

Authors:  S K Sharma; W A Klee; M Nirenberg
Journal:  Proc Natl Acad Sci U S A       Date:  1975-08       Impact factor: 11.205

2.  Isolation of the lymphocytosis promoting factor-haemagglutinin of Bordetella pertussis by affinity chromatography.

Authors:  L I Irons; A P MacLennan
Journal:  Biochim Biophys Acta       Date:  1979-09-29

3.  Possible role of cyclic nucleotides in regulation of noradrenaline release from rat pineal through presynaptic adrenoceptors.

Authors:  F Pelayo; M L Dubocovich; S Z Langer
Journal:  Nature       Date:  1978-07-06       Impact factor: 49.962

4.  Morphine-like drugs inhibit the stimulation of E prostaglandins of cyclic AMP formation by rat brain homogenate.

Authors:  H O Collier; A C Roy
Journal:  Nature       Date:  1974-03-01       Impact factor: 49.962

5.  Effect of pertussis toxin on the hormonal regulation of cyclic AMP levels in hamster fat cells.

Authors:  M A Martínez-Olmedo; J A García-Sáinz
Journal:  Biochim Biophys Acta       Date:  1983-10-18

6.  Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

Authors:  T Katada; M Ui
Journal:  Proc Natl Acad Sci U S A       Date:  1982-05       Impact factor: 11.205

7.  Pertussis vaccine inhibits the chronic but not acute action of normorphine on the myenteric plexus of guinea-pig ileum.

Authors:  H O Collier; N T Plant; J F Tucker
Journal:  Eur J Pharmacol       Date:  1983-07-22       Impact factor: 4.432

8.  Pertussis toxin blocks the action of morphine, norepinephrine and clonidine on isolated guinea-pig ileum.

Authors:  M Luján; E López; R Ramírez; H Aguilar; M A Martínez-Olmedo; J A García-Sainz
Journal:  Eur J Pharmacol       Date:  1984-05-04       Impact factor: 4.432

9.  Model of opiate dependence in the guinea-pig isolated ileum.

Authors:  H O Collier; N J Cuthbert; D L Francis
Journal:  Br J Pharmacol       Date:  1981-08       Impact factor: 8.739

10.  Pertussis toxin decreases opiate receptor binding and adenylate inhibition in a neuroblastoma x glioma hybrid cell line.

Authors:  T Costa; K Aktories; G Schultz; M Wüster
Journal:  Life Sci       Date:  1983       Impact factor: 5.037
  10 in total
  6 in total

1.  Different G proteins mediate the opioid inhibition or enhancement of evoked [5-methionine]enkephalin release.

Authors:  A R Gintzler; H Xu
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-01       Impact factor: 11.205

2.  Effects of pertussis toxin on opioid regulation of catecholamine release from rat and guinea pig brain slices.

Authors:  L L Werling; P N McMahon; B M Cox
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-05       Impact factor: 3.000

3.  Functional role of muscarinic M(2) receptors in alpha,beta-methylene ATP induced, neurogenic contractions in guinea-pig ileum.

Authors:  G W Sawyer; G Lambrecht; F J Ehlert
Journal:  Br J Pharmacol       Date:  2000-04       Impact factor: 8.739

4.  Dependence and cross-dependence in the guinea-pig myenteric plexus.

Authors:  R Schulz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-06       Impact factor: 3.000

5.  Opioid dependence prevents the action of pertussis toxin in the guinea-pig myenteric plexus.

Authors:  B Lux; R Schulz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-09       Impact factor: 3.000

6.  Effect of pretreatment with pertussis toxin on the development of physical dependence on morphine.

Authors:  M Funada; M Narita; T Suzuki; M Misawa
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-07       Impact factor: 3.000
  6 in total

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