| Literature DB >> 6541150 |
Abstract
Forskolin, a diterpene, a potent and direct stimulator of the catalytic unit of adenylate cyclase, can reduce intraocular pressure when administered topically to rabbit eyes in a 1% suspension. Using an intravitreal plant of fluorescein-dextran, aqueous flow was measured by a modification of the method of Maurice. Forskolin reduces net aqueous flow by 51% compared to the controls. Acetazolamide (25 mg kg-1) administered intravenously reduces net aqueous flow by 45%. Forskolin and acetazolamide together reduce net aqueous flow by 72%, an important additive effect undoubtedly produced by different pathways.Entities:
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Year: 1984 PMID： 6541150 DOI： 10.1016/0014-4835(84)90113-1
Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467