Literature DB >> 6540440

Immunological and spectroscopic studies of poly(dG-dC).poly(dG-dC) modified by cis-diamminedichloroplatinum(II).

J M Malinge, M Ptak, M Leng.   

Abstract

The conformational changes induced by the binding of cis-diamminedichloroplatinum(II) to poly(dG-dC).poly(dG-dC) have been studied by reaction with specific antibodies, by circular dichroism and 31P nuclear magnetic resonance. Polyclonal and monoclonal antibodies to Z-DNA bind to platinated poly(dG-dC).poly(dG-dC) at low and high ionic strength. Antibodies elicited in rabbits immunized with the platinated polynucleotide bind to double stranded polynucleotides known to adopt the Z-conformation. At low and high ionic strength the circular dichroism spectrum of platinated poly(dG-dC).poly(dG- dC) does not resemble that of poly(dG-dC).poly(dG-dC) (B or Z conformation). At low ionic strength, the characteristic 31P nuclear magnetic resonance spectrum of the Z-form is not detected. It appears only at high ionic strength, as a component of a more complex spectrum.

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Year:  1984        PMID： 6540440      PMCID： PMC320029          DOI： 10.1093/nar/12.14.5767

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  22 in total

1.  Salt-induced co-operative conformational change of a synthetic DNA: equilibrium and kinetic studies with poly (dG-dC).

Authors:  F M Pohl; T M Jovin
Journal:  J Mol Biol       Date:  1972-06-28       Impact factor: 5.469

2.  Physicochemical studies on polydeoxyribonucleotides containing defined repeating nucleotide sequences.

Authors:  R D Wells; J E Larson; R C Grant; B E Shortle; C R Cantor
Journal:  J Mol Biol       Date:  1970-12-28       Impact factor: 5.469

3.  Platinum compounds: a new class of potent antitumour agents.

Authors:  B Rosenberg; L VanCamp; J E Trosko; V H Mansour
Journal:  Nature       Date:  1969-04-26       Impact factor: 49.962

4.  Molecular structure of a left-handed double helical DNA fragment at atomic resolution.

Authors:  A H Wang; G J Quigley; F J Kolpak; J L Crawford; J H van Boom; G van der Marel; A Rich
Journal:  Nature       Date:  1979-12-13       Impact factor: 49.962

5.  "Alternating B-DNA" conformation for the oligo(dG-dC) duplex in high-salt solution.

Authors:  D J Patel; L L Canuel; F M Pohl
Journal:  Proc Natl Acad Sci U S A       Date:  1979-06       Impact factor: 11.205

6.  Bromination stabilizes poly(dG-dC) in the Z-DNA form under low-salt conditions.

Authors:  A Möller; A Nordheim; S A Kozlowski; D J Patel; A Rich
Journal:  Biochemistry       Date:  1984-01-03       Impact factor: 3.162

7.  cis-Platinum induced distortions in DNA. Conformational analysis of d(GpCpG) and cis-pt(NH3)2[d(GpCpG)], studied by 500-MHz NMR.

Authors:  J H den Hartog; C Altona; J H van Boom; A T Marcelis; G A van der Marel; L J Rinkel; G Wille-Hazeleger; J Reedijk
Journal:  Eur J Biochem       Date:  1983-08-15

8.  Spectroscopic studies of (m5dC-dG)3: thermal stability of B- and Z-forms.

Authors:  B Hartmann; N T Thuong; J Pouyet; M Ptak; M Leng
Journal:  Nucleic Acids Res       Date:  1983-07-11       Impact factor: 16.971

9.  S1 nuclease recognizes DNA conformational junctions between left-handed helical (dT-dG n. dC-dA)n and contiguous right-handed sequences.

Authors:  C K Singleton; M W Kilpatrick; R D Wells
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

10.  Nucleotide sequence of the rightward operator of phage lambda.

Authors:  T Maniatis; A Jeffrey; D G Kleid
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205
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  2 in total

1.  Electron microscopic measurement of chain flexibility of poly(dG-dC).poly(dG-dC) modified by cis-diamminedichloroplatinum(II).

Authors:  B Revet; J M Malinge; E Delain; M Le Bret; M Leng
Journal:  Nucleic Acids Res       Date:  1984-11-26       Impact factor: 16.971

2.  Reaction of nucleic acids and cis-diamminedichloroplatinum(II) in the presence of intercalating agents.

Authors:  J M Malinge; M Leng
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205
  2 in total

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