| Literature DB >> 6540415 |
R H Mattson, J A Cramer, B V Caldwell, B C Siconolfi.
Abstract
Medroxyprogesterone acetate (MPA), a synthetic progesterone, was added to the antiepileptic drug regimen of 14 women who had uncontrolled seizures. Of the 11 women who developed amenorrhea, 7 reported fewer seizures during MPA therapy. Overall reductions in seizure frequency averaged 30% (n = 11), declining from a baseline 8.3 +/- 5.8 seizures per month to 5.1 +/- 4.1 seizures per month (p = 0.02). No serious side effects were encountered, but spotting was common. These preliminary data suggest further evaluation of MPA for catamenial seizures.Entities:
Keywords: Amenorrhea; Americas; Biology; Central Nervous System; Central Nervous System Effects; Clinical Research; Clinical Trials; Connecticut; Contraception; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Female--beneficial effects; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents, Progestin--beneficial effects; Contraceptive Agents--administraction and dosage; Contraceptive Agents--beneficial effects; Contraceptive Mode Of Action; Depo-provera; Developed Countries; Diseases; Endocrine System; Family Planning; Hormones; Medroxyprogesterone Acetate--administraction and dosage; Medroxyprogesterone Acetate--beneficial effects; Menstruation Disorders; North America; Northern America; Ovulation Suppression; Physiology; Progestational Hormones; Progesterone; Prospective Studies; Research Methodology; Research Report; Studies; United States
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Year: 1984 PMID： 6540415 DOI： 10.1212/wnl.34.9.1255
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910