Inner and outer complexes of Pt-coordination compounds with DNA probed by SERS spectroscopy.

Surface enhanced Raman scattering (SERS) spectroscopy has been used to study the interfacial behaviour of DNA modified by cis-Pt(NH3)2Cl2, (cis-DDP) and [Pt-(dien)Cl]Cl bidentate and monodentate platinum coordination compounds, respectively. Two stereochemical configurations of Pt-DNA complexes can be deduced from the adsorption behaviour of the Pt adducts. The antitumoral inactive [Pt-(dien)Cl] Cl forms an outer complex whereas the antitumoral active cis-DDP favours an inner complex.