Literature DB >> 6540089

Effects of a new positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212) and its solvent sulfolane on isolated heart preparations of the rat, guinea pig, and dog.

G Grupp, I L Grupp, G Newman, A Schwartz.   

Abstract

3,4-Dihydro-6-[4-(3,4- dimethoxybenzoyl )-1-piperazinyl]-2(1H)- qu inolinone ( OPC -8212) has positive inotropic effects in guinea pig and dog isolated heart preparations. The rat heart ventricle does not respond to OPC -8212 but the atria do. OPC -8212 produces positive inotropic effects in the rat heart ventricle made hypodynamic by pretreatment with calcium entry blockers. Sulfolane , the solvent of OPC -8212, produced negative inotropic effects in most preparations. In isolated heart preparations of the rat and guinea pig, OPC -8212 produced increased coronary flow; sulfolane had only minor effects.

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Year:  1984        PMID： 6540089

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  6 in total

1.  Effect of OPC-8490 on the membrane potentials and membrane currents of single guinea-pig myocytes.

Authors:  Y Momose; S Sasayama
Journal:  Cardiovasc Drugs Ther       Date:  1990-06       Impact factor: 3.727

2.  A placebo-controlled, randomized, double-blind study of OPC-8212 in patients with mild chronic heart failure. OPC-8212 Multicenter Research Group.

Authors: 
Journal:  Cardiovasc Drugs Ther       Date:  1990-04       Impact factor: 3.727

3.  OPC-8212 in the treatment of congestive heart failure: results of a pilot study.

Authors:  S H Kubo; T S Rector; J E Strobeck; J N Cohn
Journal:  Cardiovasc Drugs Ther       Date:  1988-12       Impact factor: 3.727

4.  Cyclic AMP-dependent and cyclic AMP-independent actions of a novel cardiotonic agent, OPC-8212.

Authors:  S T Rapundalo; D A Lathrop; S A Harrison; J A Beavo; A Schwartz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-12       Impact factor: 3.000

5.  Acute hemodynamic effects of a new inotropic agent, OPC-8212, on severe congestive heart failure.

Authors:  S Sasayama; M Inoue; H Asanoi; K Kodama; M Hori; T Sakurai; C Kawai
Journal:  Heart Vessels       Date:  1986       Impact factor: 2.037

6.  Effects of a new 1,3-thiazole derivative ZSY-39 on force of contraction and cyclic AMP content in canine ventricular muscle.

Authors:  M Endoh; H Satoh; I Norota; K Hirano
Journal:  Cardiovasc Drugs Ther       Date:  1990-08       Impact factor: 3.727
  6 in total

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