Literature DB >> 6538949

Brain manganese concentrations in human aging and Alzheimer's disease.

W R Markesbery, W D Ehmann, T I Hossain, M Alauddin.   

Abstract

Manganese levels have been measured in various brain regions in Alzheimer's disease (AD) and aging using instrumental neutron activation analysis. Mn grand mean for all regions was 0.261 micrograms/g for adult controls and 0.245 micrograms/g for AD and the differences were not statistically significant (p less than 0.05). Highest Mn levels were found in the basal ganglia in controls and AD. No significant alterations in Mn were found with advancing age suggesting that the brain has an efficient homeostatic mechanism regulating Mn concentrations. Mn exhibited a significant positive correlation with Fe. Infants had a significantly lower brain Mn level compared to adults.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6538949

Source DB:  PubMed          Journal:  Neurotoxicology        ISSN： 0161-813X            Impact factor:   4.294


  12 in total

Review 1.  Cerebral magnetic resonance imaging in patients with chronic liver disease.

Authors:  M Y Morgan
Journal:  Metab Brain Dis       Date:  1998-12       Impact factor: 3.584

2.  Metal imbalance and compromised antioxidant function are early changes in prion disease.

Authors:  Alana M Thackray; Robert Knight; Stephen J Haswell; Raymond Bujdoso; David R Brown
Journal:  Biochem J       Date:  2002-02-15       Impact factor: 3.857

3.  Multi-element Analysis of Brain Regions from South African Cadavers.

Authors:  Karen Cilliers; Christo J F Muller
Journal:  Biol Trace Elem Res       Date:  2020-05-02       Impact factor: 3.738

4.  Manganese encephalopathy: utility of early magnetic resonance imaging.

Authors:  K Nelson; J Golnick; T Korn; C Angle
Journal:  Br J Ind Med       Date:  1993-06

5.  Applications of neutron activation analysis to the study of age-related neurological diseases.

Authors:  W D Ehmann; W R Markesbery; E J Kasarskis; D E Vance; S S Khare; J D Hord; C M Thompson
Journal:  Biol Trace Elem Res       Date:  1987-08       Impact factor: 3.738

6.  Zinc transporter 10 (ZnT10)-dependent extrusion of cellular Mn2+ is driven by an active Ca2+-coupled exchange.

Authors:  Moshe Levy; Nadav Elkoshi; Shiran Barber-Zucker; Eitan Hoch; Raz Zarivach; Michal Hershfinkel; Israel Sekler
Journal:  J Biol Chem       Date:  2019-02-12       Impact factor: 5.157

7.  Effect of age and dietary protein level on tissue mineral levels in female rats.

Authors:  T Takeda; M Kimura; K Yokoi; Y Itokawa
Journal:  Biol Trace Elem Res       Date:  1996-07       Impact factor: 3.738

8.  An elemental correlation study in cancerous and normal breast tissue with successive clinical stages by neutron activation analysis.

Authors:  A N Garg; V Singh; R G Weginwar; V N Sagdeo
Journal:  Biol Trace Elem Res       Date:  1994-12       Impact factor: 3.738

Review 9.  Manganese flux across the blood-brain barrier.

Authors:  Robert A Yokel
Journal:  Neuromolecular Med       Date:  2009-11-10       Impact factor: 3.843

Review 10.  Manganese neurotoxicity: lessons learned from longitudinal studies in nonhuman primates.

Authors:  Neal C Burton; Tomás R Guilarte
Journal:  Environ Health Perspect       Date:  2008-10-03       Impact factor: 9.031
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.