| Literature DB >> 6538787 |
K S Misono, H Fukumi, R T Grammer, T Inagami.
Abstract
The complete amino acid sequence of an atrial natriuretic peptide from rat possessing both natriuretic and smooth muscle relaxant activity has been determined. The peptide has the structure (sequence in text) and a calculated molecular weight of 2,706. The ring structure formed by the disulfide linkage between the two half-cystine residues was found essential for both the natriuretic activity and smooth muscle relaxant activity. The purified peptide caused 50% relaxation of norepinephrine (5 X 10(-8)M) induced contraction of rabbit thoracic aorta at the concentration of 2 X 10(-9)M and complete relaxation at 6 X 10(-9)M.Entities:
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Year: 1984 PMID： 6538787 DOI： 10.1016/s0006-291x(84)80279-x
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575