Literature DB >> 6538082

Comparative study of infectious and formaldehyde-inactivated tick-borne encephalitis virus particles.

I V Krasilnikov, L B Elbert, M K Khanina, S G Sobolev.   

Abstract

The structure and properties of infectious and formaldehyde-treated particles of tick-borne encephalitis virus, concentrated and purified by chromatography on macroporous glass, were studied. In addition to complete virions, such preparations contain some incomplete forms that differ in density, morphology and protein composition (incomplete forms do not contain nucleocapsid protein). The physico-chemical analysis of complete virions showed that formaldehyde treatment causes a) the formation of glycoprotein dimers and b) a portion of nucleocapsid protein to become tightly cross-linked with viral RNA. Formaldehyde treatment of incomplete forms resulted only in the formation of a small amount of glycoprotein dimers. Incomplete forms and glycoprotein extracted from inactivated preparations had protective and antigenic activity.

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Year:  1984        PMID： 6538082     DOI： 10.1007/bf01310814

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  20 in total

1.  ELECTRON MICROSCOPY OF A TICK-BORNE ENCEPHALITIS VIRUS.

Authors:  P WECKSTROEM; M NYHOLM
Journal:  Nature       Date:  1965-01-09       Impact factor: 49.962

2.  Characterization of tick-borne encephalitis virus and immunogenicity of its surface components in mice.

Authors:  F Heinz; C Kunz
Journal:  Acta Virol       Date:  1977-07       Impact factor: 1.162

Review 3.  Reactions of nucleic acids and nucleoproteins with formaldehyde.

Authors:  M Y Feldman
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1973

4.  Distortion of poliovirus particles by fixation with formaldehyde.

Authors:  M Wouters; A O Miller; M L Fenwick
Journal:  J Gen Virol       Date:  1973-02       Impact factor: 3.891

5.  Nomenclature of flavivirus-specified proteins.

Authors:  E G Westaway; R W Schlesinger; J M Dalrymple; D W Trent
Journal:  Intervirology       Date:  1980       Impact factor: 1.763

6.  Immunogenicity and reactogenicity of a highly purified vaccine against tick-borne encephalitis.

Authors:  C Kunz; F X Heinz; H Hofmann
Journal:  J Med Virol       Date:  1980       Impact factor: 2.327

7.  [Chromatography of formalin-inactivated tick-borne encephalitis viruses on macroporous glass].

Authors:  L B El'bert; I V Krasil'nikov; B V Mchedlishvili; V M Kolikov; M K Khanina
Journal:  Vopr Virusol       Date:  1981 Jan-Feb

8.  [Gel filtration chromatography of tick-borne encephalitis virus on macropore glass].

Authors:  I V Krasilnikov; L B El'bert; L L Mamonenko; V V Pogodina; G L Krutianskaia
Journal:  Vopr Virusol       Date:  1977 Nov-Dec

9.  [Immunological indices of human vaccination against tick-borne encephalitis using inactivated preparations with a varying concentration of the viral antigen].

Authors:  L B El'bert; Iu V Pervikov; G L Krutianskaia; I V Krasil'nikov; V P Grachev
Journal:  Zh Mikrobiol Epidemiol Immunobiol       Date:  1981-06

10.  [Formaldehyde-induced tight binding of protein to RNA in particles of rod-like virus].

Authors:  L A Mazhul'; E N Dobrov; T I Tikhonenko
Journal:  Biokhimiia       Date:  1978-01
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