Literature DB >> 6538021

Fatal hyperpyrexia after withdrawal of levodopa.

G P Sechi, F Tanda, R Mutani.   

Abstract

We studied a patient affected with idiopathic Parkinson's disease and levodopa-induced dyskinesias. Fatal hyperpyrexia followed simultaneous levodopa withdrawal and a decrease in the dosage of diphenhydramine. The clinical features were those of the neuroleptic malignant syndrome. The rapid decrease in dopaminergic activity may have been important in causing the syndrome.

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Year:  1984        PMID： 6538021     DOI： 10.1212/wnl.34.2.249

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  12 in total

1.  Parkinsonism-hyperpyrexia syndrome not related to antiparkinsonian treatment withdrawal during the 2003 summer heat wave.

Authors:  C Gaig; M J Martí; E Tolosa; M J Gómez-Choco; S Amaro
Journal:  J Neurol       Date:  2005-03-21       Impact factor: 4.849

2.  Modeling the short- and long-duration responses to exogenous levodopa and to endogenous levodopa production in Parkinson's disease.

Authors:  Phylinda L S Chan; John G Nutt; Nicholas H G Holford
Journal:  J Pharmacokinet Pharmacodyn       Date:  2004-06       Impact factor: 2.745

3.  Case files of the program in medical toxicology at brown university: amantadine withdrawal and the neuroleptic malignant syndrome.

Authors:  Eric Brantley; Jamieson Cohn; Kavita Babu
Journal:  J Med Toxicol       Date:  2009-06

4.  Apomorphine in malignant syndrome due to levodopa withdrawal.

Authors:  U Bonuccelli; P Piccini; G U Corsini; A Muratorio
Journal:  Ital J Neurol Sci       Date:  1992-03

5.  Muscle pathology in the neuroleptic malignant syndrome.

Authors:  D T Martin; M Swash
Journal:  J Neurol       Date:  1987-12       Impact factor: 4.849

6.  Levodopa withdrawal syndrome identical to neuroleptic malignant syndrome.

Authors:  W R Gibb; D N Griffith
Journal:  Postgrad Med J       Date:  1986-01       Impact factor: 2.401

Review 7.  Movement disorder emergencies.

Authors:  Kathleen L Poston; Steven J Frucht
Journal:  J Neurol       Date:  2008-08       Impact factor: 4.849

8.  Changes in body temperature markedly affect striatal dopamine release and metabolism: an in vivo study.

Authors:  T Brannan; J Martínez-Tica; M D Yahr
Journal:  J Neural Transm Gen Sect       Date:  1992

9.  The effects of acute levodopa withdrawal on motor performance and dopaminergic receptor sensitivity in patients with Parkinson's disease.

Authors:  N Turjanski; W Fernandez; A J Lees
Journal:  J Neurol Neurosurg Psychiatry       Date:  1993-07       Impact factor: 10.154

10.  Hyperthermic syndromes and impairment of the dopaminergic system: a clinical study.

Authors:  L Figà-Talamanca; C Gualandi
Journal:  Ital J Neurol Sci       Date:  1989-02
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