| Literature DB >> 653730 |
P A Meredith, M R Moore, B C Campbell, G G Thompson, A Goldberg.
Abstract
The activity of the haem biosynthetic enzymes delta-aminolaevulinic acid synthetase (ALA.S) and delta-aminolaevulinic acid dehydratase (ALA.D) were measured in the peripheral blood of a group of lead workers and control subjects. The haem precursor delta-aminolaevulinic acid (ALA) was measured in blood and urine, whilst lead levels were measured in whole blood. The inter-relationships between all these parameters were examined and quantified. The results demonstrate that above a blood lead concentration of 2 mumole/l and below an erythrocyte ALA.D activity of 18 nmole ALA utlized/min/ml red blood cells (R.B.C.), Haem synthesis is depressed to such an extent that the activity of leucocyte ALA.S, the rate-limiting enzyme of haem biosynthesis, is increased by negative feedback.Entities:
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Year: 1978 PMID： 653730 DOI： 10.1016/0300-483x(78)90026-4
Source DB: PubMed Journal: Toxicology ISSN： 0300-483X Impact factor: 4.221