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Literature DB >> 6536673

On the mechanism of inhibition of NADH oxidase by ubiquinone-3.

L Landi, P Pasquali, L Cabrini, A M Sechi, G Lenaz.

Abstract

The combined effects of rotenone and ubiquinone-3 on the kinetics of NADH dehydrogenase and NADH oxidase have been investigated. The two inhibitors do not show additivity; on the other hand, ubiquinone-3, when preincubated with the enzyme, partially removes rotenone sensitivity. The inhibition of NADH oxidase by ubiquinone-3 is the result of at least two combined effects: the competition of the less active ubiquinone-3 with endogenous ubiquinone-10 in the acceptor site of the dehydrogenase, and a nonspecific action on the structure of complex I. The latter effect is perhaps mediated by a physical change of the phospholipid bilayer similar to that observed with agents such as butanol, perturbing lipid-protein interactions in the membrane.

Entities: Chemical

Mesh：

Substances：

Year: 1984 PMID： 6536673 DOI： 10.1007/bf00743046

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

33 in total

1. STUDIES ON THE RESPIRATORY CHAIN-LINKED REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE. IX. REACTIONS WITH COENZYME Q.

Authors: J M MACHINIST; T P SINGER
Journal: J Biol Chem Date: 1965-07 Impact factor: 5.157

2. Evidence for the existence of a ubiquinone protein and its radical in the cytochromes b and c1 region in the mitochondrial electron transport chain.

Authors: C A Yu; S Nagaoka; L Yu; T E King
Journal: Biochem Biophys Res Commun Date: 1978-06-29 Impact factor: 3.575

3. The kinetics of the redox reactions of ubiquinone related to the electron-transport activity in the respiratory chain.

Authors: A Kröger; M Klingenberg
Journal: Eur J Biochem Date: 1973-04

4. Regulation of microsomal enzymes by phospholipids. II. Acitvation of hepatic uridine diphosphate-glucuronyltransferase.

Authors: D A Vessey; D Zakim
Journal: J Biol Chem Date: 1971-08-10 Impact factor: 5.157

5. Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase. XVII. Reaction sites of piericidin A and rotenone.

Authors: M Gutman; T P Singer; J E Casida
Journal: J Biol Chem Date: 1970-04-25 Impact factor: 5.157

6. Studies on the respiratory chain-linked reduced nicotinamide adenine dinucleotide dehydrogenase. 13. Binding sites of rotenone, piericidin A, and amytal in the respiratory chain.

Authors: D J Horgan; T P Singer; J E Casida
Journal: J Biol Chem Date: 1968-02-25 Impact factor: 5.157

7. On the role of ubiquinone in mitochondria. II. Redox reactions of ubiquinone under the control of oxidative phosphorylation.

Authors: A Kröger; M Klingenberg
Journal: Biochem Z Date: 1966-06-07

8. Organic structural specificity and sites of coenzyme Q in succinoxidase and DPNH-oxidase systems.

Authors: G Lenaz; G D Daves; K Kfolkers
Journal: Arch Biochem Biophys Date: 1968-03-11 Impact factor: 4.013

9. Lipid protein interactions in mitochondria. VII. A comparison of the effects of lipid removal and lipid perturbation of the kinetic properties of mitochondrial ATPase.

Authors: G Parenti-Castelli; A M Sechi; L Landi; L Cabrini; S Mascarello; G Lenaz
Journal: Biochim Biophys Acta Date: 1979-07-10