Literature DB >> 653315

Platelet activation: a new biological activity of guinea-pig C3a anaphylatoxin.

S Becker, S Meuer, U Hadding, D Bitter-Suermann.   

Abstract

3H-serotonin-release from labelled gp-platelets is established as a sensitive method for testing a new biological activity of gp-C3a anaphylatoxin in an autologous situation. Time-, dose- and temperature-dependent release reactions as well as specific inhibition by carboxypeptidase B and anti-C3a antibodies show that C3a is a potent and specific inducer of platelet activation. Inactive C3a does not induce 3H-serotonin-release but specifically inhibits the action of C3a on platelets.

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Year:  1978        PMID： 653315     DOI： 10.1111/j.1365-3083.1978.tb00441.x

Source DB:  PubMed          Journal:  Scand J Immunol        ISSN： 0300-9475            Impact factor:   3.487


  8 in total

1.  Functional activities of synthetic anaphylatoxic peptides in widely used biological assays.

Authors:  A Kola; A Klos; W Bautsch; T Kretzschmar; J Köhl
Journal:  Clin Exp Immunol       Date:  1992-05       Impact factor: 4.330

2.  Evidence for in vivo degradation of C3a anaphylatoxin by mast cell chymase. I. Nonspecific activation of rat peritoneal mast cells by C3ades Arg.

Authors:  T Kajita; T E Hugli
Journal:  Am J Pathol       Date:  1991-06       Impact factor: 4.307

Review 3.  Relationships among the complement, kinin, coagulation, and fibrinolytic systems.

Authors:  J S Sundsmo; D S Fair
Journal:  Springer Semin Immunopathol       Date:  1983

4.  Comparative study on biological activities of various anaphylatoxins (C4a, C3a, C5a). Investigations on their ability to induce platelet secretion.

Authors:  S Meuer; T E Hugli; R H Andreatta; U Hadding; D Bitter-Suermann
Journal:  Inflammation       Date:  1981-12       Impact factor: 4.092

5.  Design and biological activity of a new generation of synthetic C3a analogues by combination of peptidic and non-peptidic elements.

Authors:  R Gerardy-Schahn; D Ambrosius; M Casaretto; J Grötzinger; D Saunders; A Wollmer; D Brandenburg; D Bitter-Suermann
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

6.  Low zone desensitization: a stimulus-specific control mechanism of cell response. Investigations on anaphylatoxin-induced platelet secretion.

Authors:  S Meuer; B Zanker; U Hadding; D Bitter-Suermann
Journal:  J Exp Med       Date:  1982-03-01       Impact factor: 14.307

7.  Human platelet activation by C3a and C3a des-arg.

Authors:  M J Polley; R L Nachman
Journal:  J Exp Med       Date:  1983-08-01       Impact factor: 14.307

Review 8.  Complement mediators: key regulators of airway tissue remodeling in asthma.

Authors:  Mohammad Afzal Khan; Abdullah Mohammed Assiri; Dieter Clemens Broering
Journal:  J Transl Med       Date:  2015-08-20       Impact factor: 5.531
  8 in total

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