Literature DB >> 6532801

Structure reactivity relationships in the microsomal oxidation of tertiary amines.

G Galliani, B Rindone, G Dagnino, M Salmona.   

Abstract

Apparent kinetic parameters Vmax and KM have been measured for the oxidative N-demethylation of twelve para-substituted N, N-dimethylanilines catalysed by rat liver microsomes. Vmax was enhanced by pretreatment of the rats with phenobarbital, whereas pretreatment with beta-naphthoflavone gave no appreciable enhancement. In the case of phenobarbital pretreatment the kinetic parameters could be expressed in terms of lipophilic and electronic effect of the substituents. Kinetic parameters from control and beta-naphthoflavone microsomes gave no statistically meaningful correlation.

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Year:  1984        PMID： 6532801     DOI： 10.1007/BF03189678

Source DB:  PubMed          Journal:  Eur J Drug Metab Pharmacokinet        ISSN： 0378-7966            Impact factor:   2.441


  9 in total

1.  The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.

Authors:  T NASH
Journal:  Biochem J       Date:  1953-10       Impact factor: 3.857

2.  Application and interpretation of kinetic analyses from the microsomal drug metabolizing oxygenases.

Authors:  W Lenk
Journal:  Biochem Pharmacol       Date:  1976-05-01       Impact factor: 5.858

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

4.  Hydroxylation of aniline and aminoantipyrine (1-phenyl-2,3-dimethyl-aminopyrasolon-5) derivatives in liver endoplasmatic reticulum.

Authors:  A I Archakov; I I Karuzina; V N Tveritinov; I S Kokareva
Journal:  Biochem Pharmacol       Date:  1974-03-15       Impact factor: 5.858

5.  "Aromatic" substituent constants for structure-activity correlations.

Authors:  C Hansch; A Leo; S H Unger; K H Kim; D Nikaitani; E J Lien
Journal:  J Med Chem       Date:  1973-11       Impact factor: 7.446

6.  Differences among the action of phenobarbital, methylcholanthrene and male sex hormone on microsomal drug-metabolizing enzyme systems of rat liver.

Authors:  R Kato; M Takayanaghi
Journal:  Jpn J Pharmacol       Date:  1966-12

7.  Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines.

Authors:  F F Kadlubar; K C Morton; D M Ziegler
Journal:  Biochem Biophys Res Commun       Date:  1973-10-15       Impact factor: 3.575

8.  Liver metabolic reactions: tertiary amine N-dealkylation, tertiary amine N-oxidation, N-oxide reduction, and N-oxide N-dealkylation. II. N,N-dimethylaniline.

Authors:  P Willi; M H Bickel
Journal:  Arch Biochem Biophys       Date:  1973-06       Impact factor: 4.013

9.  [Influence of substituants on microsomal dealkylation of aromatic N-, O-, and S-alkyl compounds].

Authors:  H L Schmidt; M R Möller; N Weber
Journal:  Biochem Pharmacol       Date:  1973-12-01       Impact factor: 5.858
  9 in total
  2 in total

1.  Pharmacokinetics and metabolism of hexamethylmelamine in mice after IP administration.

Authors:  J Dubois; G Atassi; M Hanocq; F Abikhalil
Journal:  Cancer Chemother Pharmacol       Date:  1986       Impact factor: 3.333

2.  Bio-activation of 4-alkyl analogs of 1,4-dihydropyridine mediated by cytochrome P450 enzymes.

Authors:  Xiao-Xi Li; Xiaoqian Zhang; Qing-Chuan Zheng; Yong Wang
Journal:  J Biol Inorg Chem       Date:  2015-03-18       Impact factor: 3.358
  2 in total

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