Literature DB >> 6530848

Circulating immune complexes in gastric cancer patients and their effect on lymphocyte mitogenesis (the first report).

Y Osaki, S Koga, M Maeta, N Shimizu, H Kanayama, R Hamazoe.   

Abstract

Immune complexes (IC) were measured in 66 gastric cancer patients, using the 3.5 percent polyethylene glycol (PEG) precipitation method. Preoperatively, the IC values in patients with advanced gastric cancer (stages III and IV) were significantly higher than in normal subjects (p less than 0.01). In the presence of 3.5 percent PEG-precipitated IC from sera of gastric cancer patients, the mitogen responses of normal peripheral blood lymphocytes was inhibited; the PHA response revealed a significant negative correlation with the concentration of IC (p less than 0.01). Our data suggest that IC may be a major serum factor exerting immunosuppressive effect in cancer hosts.

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Year:  1984        PMID： 6530848     DOI： 10.1007/bf02469797

Source DB:  PubMed          Journal:  Jpn J Surg        ISSN： 0047-1909


  7 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  The nature of immune complexes in human cancer sera.

Authors:  A N Theofilopoulos; B S Andrews; M M Urist; D L Morton; F J Dixon
Journal:  J Immunol       Date:  1977-08       Impact factor: 5.422

3.  Detection of circulating immune complexes in human sera by simplified assays with polyethylene glycol.

Authors:  M Digeon; M Laver; J Riza; J F Bach
Journal:  J Immunol Methods       Date:  1977       Impact factor: 2.303

4.  The general rules for the gastric cancer study in surgery and pathology. Part I. Clinical classification.

Authors:  T Kajitani
Journal:  Jpn J Surg       Date:  1981-03

5.  Elution of "blocking factors" from human tumors, capable of abrogating tumor-cell destruction by specifically immune lymphocytes.

Authors:  H O Sjögren; I Hellström; S C Bansal; G A Warner; K E Hellström
Journal:  Int J Cancer       Date:  1972-03-15       Impact factor: 7.396

6.  The C1q binding test for soluble immune complexes: clinical correlations obtained in patients with cancer.

Authors:  R D Rossen; M A Reisberg; E M Hersh; J U Gutterman
Journal:  J Natl Cancer Inst       Date:  1977-05       Impact factor: 13.506

7.  Circulating immune complexes detected by 125I-Clq deviation test in sera of cancer patients.

Authors:  H Teshima; H Wanebo; C Pinsky; N K Day
Journal:  J Clin Invest       Date:  1977-06       Impact factor: 14.808
  7 in total
  1 in total

1.  Complement receptor 1 genetic variants contribute to the susceptibility to gastric cancer in chinese population.

Authors:  Lina Zhao; Zhi Zhang; Jia Lin; Lei Cao; Bing He; Sugui Han; Xuemei Zhang
Journal:  J Cancer       Date:  2015-04-05       Impact factor: 4.207
  1 in total

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