Literature DB >> 6529966

Clozapine blocks disruptive and discriminative stimulus effects of quipazine.

R L Friedman, E Sanders-Bush, R L Barrett.   

Abstract

Clozapine was tested in two serotonin-dependent behavioral measures. One group of rats was trained to discriminate the serotonin agonist, quipazine, from saline in a two-lever operant choice task. Pretreatment with clozapine completely blocked the discrimination of quipazine. Another group of rats was trained to bar press for milk on a variable interval schedule of reinforcement. Quipazine decreased the response rate in these animals and pretreatment with clozapine completely reversed this effect. Thus, clozapine acted as a serotonin antagonist in both measures of serotonin function.

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Year:  1984        PMID： 6529966     DOI： 10.1016/0014-2999(84)90695-2

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Trends in drug discrimination research analysed with a cross-indexed bibliography, 1984-1987.

Authors:  I P Stolerman; F Rasul; P J Shine
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

2.  Acute dystonia due to clozapine.

Authors:  O Kastrup; M Gastpar; M Schwarz
Journal:  J Neurol Neurosurg Psychiatry       Date:  1994-01       Impact factor: 10.154

3.  Clozapine pharmacology and tardive dyskinesia.

Authors:  J Lieberman; C Johns; T Cooper; S Pollack; J Kane
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

4.  Olanzapine, an atypical antipsychotic, increases rates of punished responding in pigeons.

Authors:  M J Benvenga; J D Leander
Journal:  Psychopharmacology (Berl)       Date:  1995-05       Impact factor: 4.530

5.  Discriminative stimulus properties of the atypical antipsychotic clozapine and the typical antipsychotic chlorpromazine in a three-choice drug discrimination procedure in rats.

Authors:  Joseph H Porter; Adam J Prus; Robert E Vann; Stephen A Varvel
Journal:  Psychopharmacology (Berl)       Date:  2004-08-13       Impact factor: 4.530

Review 6.  The role of serotonin in schizophrenia: an overview of the nomenclature, distribution and alterations of serotonin receptors in the central nervous system.

Authors:  D C Ohuoha; T M Hyde; J E Kleinman
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

7.  The dopamine-serotonin relationship in clozapine response.

Authors:  S Szymanski; J Lieberman; S Pollack; R Munne; A Safferman; J Kane; M Kronig; T Cooper
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

Review 8.  Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia.

Authors:  H Y Meltzer
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530
  8 in total

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