Literature DB >> 6528058

Large bowel stenosis in rats after fractionated local irradiation.

Z Kiszel, A Spiethoff, K R Trott.   

Abstract

After local irradiation of the distal large bowel rats may develop fatal large bowel stenosis within 200 days. The incidence rises steeply with dose. The LD50 for single dose irradiation is 20 Gy. The tolerance of the large bowel to local irradiation depends strongly on dose fractionation. Extending the intervals between the fractions and decreasing the dose per fraction both have a pronounced dose-sparing effect.

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Year:  1984        PMID： 6528058     DOI： 10.1016/s0167-8140(84)80065-1

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN： 0167-8140            Impact factor:   6.280


  6 in total

1.  The pathogenesis of the chronic radiation ulcer of the large bowel in rats.

Authors:  N Breiter; K R Trott
Journal:  Br J Cancer Suppl       Date:  1986

2.  Early and late effects of irradiation on morphometry and residual strain of mouse rectum.

Authors:  Hans Gregersen; Lilli Lundby; Jens Overgaard
Journal:  Dig Dis Sci       Date:  2002-07       Impact factor: 3.199

3.  Radiation-induced proctitis cystica profunda in the rat.

Authors:  K R Geisinger; M W Scobey; M G Northway; K T Cassidy; D O Castell
Journal:  Dig Dis Sci       Date:  1990-07       Impact factor: 3.199

4.  The effect of probiotics for preventing radiation-induced morphological changes in intestinal mucosa of rats.

Authors:  Yongkan Ki; Wontaek Kim; Heunglae Cho; Kijung Ahn; Youngmin Choi; Dongwon Kim
Journal:  J Korean Med Sci       Date:  2014-10-08       Impact factor: 2.153

5.  Low-Dose Aspirin Therapy Does not Increase the Severity of Acute Radiation Proctitis.

Authors:  Hiroshi Doi; Norihiko Kamikonya; Yasuhiro Takada; Yasue Niwa; Masayuki Fujiwara; Keita Tsuboi; Hideharu Miura; Hiroyuki Inoue; Masao Tanooka; Takeshi Nakamura; Toshiyuki Shikata; Takeshi Kimura; Tohru Tsujimura; Shozo Hirota
Journal:  World J Oncol       Date:  2012-08-26

6.  Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.

Authors:  John O Archambeau; Artak Tovmasyan; Robert D Pearlstein; James D Crapo; Ines Batinic-Haberle
Journal:  Redox Biol       Date:  2013-10-25       Impact factor: 11.799
  6 in total

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