Literature DB >> 6527754

Low doses of brotizolam and nitrazepam as hypnotics in the elderly.

M Viukari, T Vartio, E Verho.   

Abstract

0.125 mg brotizolam and 2.5 mg nitrazepam proved to be equipotent in promoting and maintaining sleep in 29 elderly patients used to long-term hypnotics. These drugs were superior to placebo and they were excellently tolerated. The drugs were administered in a random order, double-blind, for 7 nights each.

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Year:  1984        PMID： 6527754     DOI： 10.1159/000118125

Source DB:  PubMed          Journal:  Neuropsychobiology        ISSN： 0302-282X            Impact factor:   2.328


  5 in total

Review 1.  Clinical pharmacokinetics of anxiolytics and hypnotics in the elderly. Therapeutic considerations (Part II).

Authors:  D J Greenblatt; J S Harmatz; R I Shader
Journal:  Clin Pharmacokinet       Date:  1991-10       Impact factor: 6.447

Review 2.  Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits.

Authors:  Jennifer Glass; Krista L Lanctôt; Nathan Herrmann; Beth A Sproule; Usoa E Busto
Journal:  BMJ       Date:  2005-11-11

3.  Meta-analysis of benzodiazepine use in the treatment of insomnia.

Authors:  A M Holbrook; R Crowther; A Lotter; C Cheng; D King
Journal:  CMAJ       Date:  2000-01-25       Impact factor: 8.262

Review 4.  Brotizolam. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy as an hypnotic.

Authors:  M S Langley; S P Clissold
Journal:  Drugs       Date:  1988-02       Impact factor: 9.546

Review 5.  Prescription Benzodiazepine Use Among Older Adults: A Critical Review.

Authors:  Lauren B Gerlach; Ilse R Wiechers; Donovan T Maust
Journal:  Harv Rev Psychiatry       Date:  2018 Sep/Oct       Impact factor: 3.732
  5 in total

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