Literature DB >> 6527537

Identification of 24-hydroxycholesterol in bovine adrenals in both free and esterified forms and in bovine brains as its sulfate ester.

V V Prasad, L Ponticorvo, S Lieberman.   

Abstract

24-Hydroxycholesterol was found to be present in bovine adrenals in a concentration of 2-3 micrograms/kg and in larger amounts (10-12 micrograms/kg) as a saponifiable ester. No solvolyzable sulfate ester was detected. In bovine brains, however, the sulfate ester of this sterol was found in a concentration of 84 micrograms/kg. A procedure for the synthesis of [7-3H] 24S-hydroxycholesterol is described.

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Year:  1984        PMID： 6527537     DOI： 10.1016/0022-4731(84)90038-4

Source DB:  PubMed          Journal:  J Steroid Biochem        ISSN： 0022-4731            Impact factor:   4.292


  2 in total

1.  Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain.

Authors:  Natalia Mast; Mark Andrew White; Ingemar Bjorkhem; Eric F Johnson; C David Stout; Irina A Pikuleva
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-09       Impact factor: 11.205

2.  Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation.

Authors:  D Lütjohann; O Breuer; G Ahlborg; I Nennesmo; A Sidén; U Diczfalusy; I Björkhem
Journal:  Proc Natl Acad Sci U S A       Date:  1996-09-03       Impact factor: 11.205
  2 in total

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