Literature DB >> 6527235

General treatment of pH-solubility profiles of weak acids and bases and the effects of different acids on the solubility of a weak base.

W H Streng, S K Hsi, P E Helms, H G Tan.   

Abstract

The pH-solubility profile of a weak acid or base is shown to be a function of its pKsp, pKa, and uncharged species solubility. Equations are presented that can be used to calculate the solubility as a function of pH. These equations can also be used when there is added salt present. Experimental data was obtained in three cosolvent systems consisting of methanol-water and ethanol-water. Also, the effect of different acids on the solubility of a weak base is reported. A pronounced effect on the solubility by the addition of salt is explained in terms of the Ksp.

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Year:  1984        PMID： 6527235     DOI： 10.1002/jps.2600731203

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  8 in total

1.  The composite solubility versus pH profile and its role in intestinal absorption prediction.

Authors:  Barry A Hendriksen; Manuel V Sanchez Felix; Michael B Bolger
Journal:  AAPS PharmSci       Date:  2003

2.  Carvedilol: solubilization and cyclodextrin complexation: a technical note.

Authors:  Thorsteinn Loftsson; Stine Byskov Vogensen; Cyrielle Desbos; Phatsawee Jansook
Journal:  AAPS PharmSciTech       Date:  2008-03-05       Impact factor: 3.246

3.  Estimating the Aqueous Solubility of Pharmaceutical Hydrates.

Authors:  Stephen J Franklin; Usir S Younis; Paul B Myrdal
Journal:  J Pharm Sci       Date:  2016-06       Impact factor: 3.534

4.  Exploratory Study on Lercanidipine Hydrochloride Polymorphism: pH-Dependent Solubility Behavior and Simulation of its Impact on Pharmacokinetics.

Authors:  Ilia Alekseevich Repin; Raimar Loebenberg; John DiBella; António C L Conceição; Manuel E Minas da Piedade; Humberto G Ferraz; Michele G Issa; Nadia A Bou-Chacra; Catharine F M Ermida; Gabriel L B de Araujo
Journal:  AAPS PharmSciTech       Date:  2021-01-21       Impact factor: 3.246

5.  Structure-property relations of a unique and systematic dataset of 19 isostructural multicomponent apremilast forms.

Authors:  Jan Jirát; Martin Babor; Luděk Ridvan; Eliška Skořepová; Michal Dušek; Miroslav Šoóš
Journal:  IUCrJ       Date:  2022-06-15       Impact factor: 5.588

6.  Estimation of intragastric solubility of drugs: in what medium?

Authors:  Maria Vertzoni; Eleni Pastelli; Dimitris Psachoulias; Lida Kalantzi; Christos Reppas
Journal:  Pharm Res       Date:  2007-03-20       Impact factor: 4.580

7.  Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database.

Authors:  Alex Avdeef
Journal:  ADMET DMPK       Date:  2020-03-04

Review 8.  Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations.

Authors:  Benjamin Gabriel Poulson; Kacper Szczepski; Joanna Izabela Lachowicz; Lukasz Jaremko; Abdul-Hamid Emwas; Mariusz Jaremko
Journal:  RSC Adv       Date:  2019-12-24       Impact factor: 4.036
  8 in total

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