Literature DB >> 6527007

In vivo activation of macrophages but not natural killer cells by picolinic acid (PLA).

R Ruffmann, R D Welker, T Saito, M A Chirigos, L Varesio.   

Abstract

Intraperitoneal injection of PLA into C57BL/6 mice induced high levels of macrophage-mediated cytostatic activity. Maximal cytostatic activity was found 3 days after injection of 100 mg/kg of PLA. In contrast, natural killer cell activity was not affected by PLA. Thus, PLA selectively modulates macrophage activity without influencing NK activity.

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Year:  1984        PMID： 6527007     DOI： 10.3109/08923978409028605

Source DB:  PubMed          Journal:  J Immunopharmacol        ISSN： 0163-0571


  4 in total

1.  Protective effect of picolinic acid on mice intracerebrally infected with lethal doses of Candida albicans.

Authors:  E Blasi; R Mazzolla; L Pitzurra; R Barluzzi; F Bistoni
Journal:  Antimicrob Agents Chemother       Date:  1993-11       Impact factor: 5.191

2.  Differential host susceptibility to intracerebral infections with Candida albicans and Cryptococcus neoformans.

Authors:  E Blasi; R Barluzzi; R Mazzolla; F Bistoni
Journal:  Infect Immun       Date:  1993-08       Impact factor: 3.441

3.  A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

Authors:  G Melillo; T Musso; A Sica; L S Taylor; G W Cox; L Varesio
Journal:  J Exp Med       Date:  1995-12-01       Impact factor: 14.307

Review 4.  Understanding the role of the kynurenine pathway in human breast cancer immunobiology.

Authors:  Benjamin Heng; Chai K Lim; David B Lovejoy; Alban Bessede; Laurence Gluch; Gilles J Guillemin
Journal:  Oncotarget       Date:  2016-02-09
  4 in total

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