Literature DB >> 6526218

Disruptive effect of diethylstilbestrol on microtubules.

Y Sato, T Murai, M Tsumuraya, H Saitô, M Kodama.   

Abstract

Diethylstilbestrol, a unique carcinogen lacking measurable mutagenic potency in Salmonella, was shown to be an inhibitor of microtubule assembly in vitro using microtubule proteins isolated from porcine brains. The effective concentration of diethylstilbestrol was 10-200 microM, as determined by viscometry, turbidity measurement, and electron microscopic analysis.

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Year:  1984        PMID: 6526218

Source DB:  PubMed          Journal:  Gan        ISSN: 0016-450X


  4 in total

Review 1.  Neoplastic transformation of cultured mammalian cells by estrogens and estrogenlike chemicals.

Authors:  T Tsutsui; J C Barrett
Journal:  Environ Health Perspect       Date:  1997-04       Impact factor: 9.031

2.  Effects of estrogens on microtubule polymerization in vitro: correlation with estrogenicity.

Authors:  M Metzler; E Pfeiffer
Journal:  Environ Health Perspect       Date:  1995-10       Impact factor: 9.031

Review 3.  Estrogens-Origin of Centrosome Defects in Human Cancer?

Authors:  Miriam Bühler; Ailine Stolz
Journal:  Cells       Date:  2022-01-27       Impact factor: 6.600

Review 4.  Mechanisms of multistep carcinogenesis and carcinogen risk assessment.

Authors:  J C Barrett
Journal:  Environ Health Perspect       Date:  1993-04       Impact factor: 9.031

  4 in total

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