Literature DB >> 6526217

Gamma-irradiation induces mutation in ataxia-telangiectasia lymphoblastoid cells.

K Tatsumi, H Takebe.   

Abstract

Ataxia-telangiectasia (AT) cells are hypersensitive to the lethal effect of gamma-rays, whereas little or no gamma-ray induced mutation has been observed. In this work, exposure to gamma-rays of an Epstein-Barr virus-transformed AT lymphoblastoid cell line, GM2783, resulted in a clear dose-dependent increase of mutation for 6-thioguanine resistance.

Entities:  

Mesh：

Year:  1984        PMID： 6526217

Source DB:  PubMed          Journal:  Gan        ISSN： 0016-450X


  3 in total

1.  Evidence for an elevated frequency of in vivo somatic cell mutations in ataxia telangiectasia.

Authors:  W L Bigbee; R G Langlois; M Swift; R H Jensen
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

2.  Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation.

Authors:  F Xia; S A Amundson; J A Nickoloff; H L Liber
Journal:  Mol Cell Biol       Date:  1994-09       Impact factor: 4.272

3.  High frequency of deletions at the hypoxanthine-guanine phosphoribosyltransferase locus in an ataxia-telangiectasia lymphoblastoid cell line irradiated with gamma-rays.

Authors:  A Tachibana; K Tatsumi; I Furuno-Fukushi; M S Sasaki
Journal:  Jpn J Cancer Res       Date:  2001-11
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.