Literature DB >> 652527

Enzymes from Micrococcus luteus involved in the initial steps of excision repair of spontaneous DNA lesions: uracil-DNA-glycosidase and apurinic-endonucleases.

N V Tomlin, O N Aprelikova, L S Barenfeld.   

Abstract

Uracil-DNA-glycosidase that releases free uracil from single-stranded or double-stranded deaminated DNA and poly d(A-U) has been partially purified from Micrococcus luteus. The enzyme has a molecular weight of about 16,000 and can be separated from uracil-endonuclease and endonucleases (AP-endonucleases) specific for apurinic and apyrimidinic sites. Uracil-DNA-glycosidase does not act on guanine residues opposite uracil in double-stranded DNA and on xanthine in deaminated DNA. The glycosidase generates apyrimidinic sites which can serve as substrate sites for different AP-endonucleases from M. luteus.

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Year:  1978        PMID： 652527      PMCID： PMC342088          DOI： 10.1093/nar/5.4.1413

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  13 in total

1.  Heat mutagenesis in bacteriophage T4: the transition pathway.

Authors:  R H Baltz; P M Bingham; J W Drake
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

2.  EFFECTS OF HEATING DRY BACTERIA AND SPORES ON THEIR PHENOTYPE AND GENOTYPE.

Authors:  S Zamenhof
Journal:  Proc Natl Acad Sci U S A       Date:  1960-01       Impact factor: 11.205

3.  Substrate specificity of the ultraviolet-endonuclease from Micrococcus luteus. Endonucleolytic cleavage of depurinated DNA.

Authors:  N V Tomilin; E B Paveltchuk; T V Mosevitskaya
Journal:  Eur J Biochem       Date:  1976-10-01

4.  DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli.

Authors:  T Lindahl; S Ljungquist; W Siegert; B Nyberg; B Sperens
Journal:  J Biol Chem       Date:  1977-05-25       Impact factor: 5.157

5.  Heat-induced deamination of cytosine residues in deoxyribonucleic acid.

Authors:  T Lindahl; B Nyberg
Journal:  Biochemistry       Date:  1974-07-30       Impact factor: 3.162

6.  DNA methylated in vitro by a monofunctional alkylating agent as a substrate for a specific nuclease from Micrococcus lysodeikticus.

Authors:  B S Strauss; M Robbins
Journal:  Biochim Biophys Acta       Date:  1968-06-18

7.  Endonuclease II of Escherichia coli. Degradation of partially depurinated deoxyribonucleic acid.

Authors:  S M Hadi; D A Goldthwait
Journal:  Biochemistry       Date:  1971-12-21       Impact factor: 3.162

8.  Endonuclease V of Escherichia coli.

Authors:  F T Gates; S Linn
Journal:  J Biol Chem       Date:  1977-03-10       Impact factor: 5.157

9.  Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA.

Authors:  B K Tye; P O Nyman; I R Lehman; S Hochhauser; B Weiss
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

10.  An N-glycosidase from Escherichia coli that releases free uracil from DNA containing deaminated cytosine residues.

Authors:  T Lindahl
Journal:  Proc Natl Acad Sci U S A       Date:  1974-09       Impact factor: 11.205
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  3 in total

Review 1.  DNA glycosylases.

Authors:  S J Caradonna; Y C Cheng
Journal:  Mol Cell Biochem       Date:  1982-07-07       Impact factor: 3.396

2.  Partial Purification and Characterization of Uracil-DNA Glycosylase Activity from Chloroplasts of Zea mays Seedlings.

Authors:  R J Bensen; H R Warner
Journal:  Plant Physiol       Date:  1987-08       Impact factor: 8.340

3.  The Skin Microbiome: Is It Affected by UV-induced Immune Suppression?

Authors:  VijayKumar Patra; Scott N Byrne; Peter Wolf
Journal:  Front Microbiol       Date:  2016-08-10       Impact factor: 5.640
  3 in total

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