Literature DB >> 6524914

Microbial contamination of a vitamin A formulation, prepared in local pharmacies, and its preservation against yeasts and moulds.

H van Doorne, W A Scheffers, M Hadiutomo, E van den Bosch.   

Abstract

The microbial contamination of 44 samples of a vitamin A preparation in sucrose syrup was investigated. The contaminants were almost exclusively yeasts and moulds. Microbiological and physicochemical studies showed that sorbic acid was the preservative of choice for this formulation. The results are discussed with respect to the preservation of non-sterile pharmaceuticals.

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Year:  1984        PMID： 6524914     DOI： 10.1007/bf00394655

Source DB:  PubMed          Journal:  Antonie Van Leeuwenhoek        ISSN： 0003-6072            Impact factor:   2.271


  9 in total

1.  Potentiation of preservatives (parabens) in pharmaceutical formulations by low concentrations of propylene glycol.

Authors:  P S PRICKETT; H L MURRAY; N H MERCER
Journal:  J Pharm Sci       Date:  1961-04       Impact factor: 3.534

2.  Evaluating preservative efficacy by challenge testing during the development stage of pharmaceutical products.

Authors:  K E Moore
Journal:  J Appl Bacteriol       Date:  1978-06

3.  Critique of U.S.P. microbiological test.

Authors:  M Leitz
Journal:  Bull Parenter Drug Assoc       Date:  1972 Sep-Oct

4.  Fundamental concepts of preservation.

Authors:  J I Yablonski
Journal:  Bull Parenter Drug Assoc       Date:  1972 Sep-Oct

5.  The instability of antimicrobial preservatives.

Authors:  L Lachman
Journal:  Bull Parenter Drug Assoc       Date:  1968 May-Jun

Review 6.  Preservation of emulsions against microbial attack.

Authors:  D L Wedderburn
Journal:  Adv Pharm Sci       Date:  1964

7.  Antimicrobial agents as preservatives in pharmaceutical and cosmetic products. Introduction: The scope of the problem.

Authors:  W B Hugo
Journal:  J Appl Bacteriol       Date:  1978-06

8.  An alternate approach for preservative testing of ophthalmic multiple-dose products.

Authors:  R D Houlsby
Journal:  J Parenter Drug Assoc       Date:  1980 Jul-Aug

9.  Effect of sorbitol on interaction of phenolic preservatives with polysorbate 80.

Authors:  J Blanchard; W T Fink; J P Duffy
Journal:  J Pharm Sci       Date:  1977-10       Impact factor: 3.534
  9 in total

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