Literature DB >> 6524529

Clinical pharmacology of GP53,633--a new non-steroidal anti-inflammatory drug--in patients with rheumatoid arthritis.

S Wanwimolruk, D Thomas, D J Birkett, J O Miners, P M Brooks.   

Abstract

GP53,633 is a new basic non-steroidal anti-inflammatory drug showing analgesic and anti-inflammatory activity in animal models. Pharmacokinetic studies in 6 patients with rheumatoid arthritis show it to be rapidly absorbed with a short half life (approximately 2 hours). No change in pharmacokinetics is seen over a two week treatment period. Clinical parameters of inflammation were reduced and no adverse reactions were seen.

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Year:  1984        PMID: 6524529     DOI: 10.1007/bf01972382

Source DB:  PubMed          Journal:  Agents Actions        ISSN: 0065-4299


  6 in total

1.  DIAGNOSTIC criteria for rheumatoid arthritis: 1958 revision by a committee of the American Rheumatism Association.

Authors: 
Journal:  Ann Rheum Dis       Date:  1959-03       Impact factor: 19.103

2.  Clinical studies with an articular index for the assessment of joint tenderness in patients with rheumatoid arthritis.

Authors:  D M Ritchie; J A Boyle; J M McInnes; M K Jasani; T G Dalakos; P Grieveson; W W Buchanan
Journal:  Q J Med       Date:  1968-07

3.  Protein binding of GP53,633: a basic non-steroidal anti-inflammatory drug.

Authors:  S Wanwimolruk; D J Birkett; P M Brooks
Journal:  Biochem Pharmacol       Date:  1982-12-01       Impact factor: 5.858

4.  Four new anti-inflammatory drugs: responses and variations.

Authors:  E C Huskisson; D L Woolf; H W Balme; J Scott; S Franklin
Journal:  Br Med J       Date:  1976-05-01

5.  Clinical comparison of ibuprofen, fenoprofen calcium, naproxen and tolmetin sodium in rheumatoid arthritis.

Authors:  E P Gall; E M Caperton; J E McComb; R Messner; C V Multz; M O'Hanlan; R F Willkens
Journal:  J Rheumatol       Date:  1982 May-Jun       Impact factor: 4.666

6.  Diclofenac sodium, diflunisal and naproxen: patient preferences for anti-inflammatory drugs in rheumatoid arthritis.

Authors:  E C Huskisson; P A Dieppe; J Scott; H Jones
Journal:  Rheumatol Rehabil       Date:  1982-11
  6 in total

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