Literature DB >> 6521508

Heterochromatinization as a key factor in aging.

T A Lezhava.   

Abstract

An analysis of observations on modifications during aging of the characteristics of chromosomes during the mitotic cycle of their mutations and unscheduled aging leads to the conclusion that enhanced heterochromatinization during aging prevents the action of reparative enzymes, and results in increased numbers of cells with chromosomal aberrations.

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Year:  1984        PMID： 6521508     DOI： 10.1016/0047-6374(84)90028-9

Source DB:  PubMed          Journal:  Mech Ageing Dev        ISSN： 0047-6374            Impact factor:   5.432


  2 in total

1.  Loss of expression of a differentiated function gene, steroid 17 alpha-hydroxylase, as adrenocortical cells senescence in culture.

Authors:  P J Hornsby; J P Hancock; T P Vo; L M Nason; R F Ryan; J M McAllister
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

Review 2.  Gerontology research in Georgia.

Authors:  Teimuraz Lezhava; Jamlet Monaselidze; Tina Jokhadze; Nona Kakauridze; Nodar Khodeli; Mamanti Rogava; Tamara Bochorishvili; Maia Gorgoshidze; Dato Khachidze; Eteri Lomidze; Jaba Tkemaladze; Kote Chichinadze; Marina Koridze; Rusudan Khukhuneishvili; Nato Zosidze; Marina Nagervadze; Tamara Buadze; Maia Gaiozishvili
Journal:  Biogerontology       Date:  2010-05-18       Impact factor: 4.277
  2 in total

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