| Literature DB >> 6520886 |
R C Wester, H I Maibach, D A Bucks, M B Aufrere.
Abstract
This study determines the in vivo percutaneous absorption of paraquat in humans. Three skin sites of application were used in a crossover manner for six subjects. The percents of applied dose (9 micrograms/cm2) absorbed were 0.29 +/- 0.2 (SD) for the leg, 0.23 +/- 0.1 for the hand, and 0.29 +/- 0.1 for the forearm. This gives an in vivo absorption rate of 0.03 microgram/cm2 for the 24-h exposure. Paraquat can be absorbed in vivo through the skin of humans; however, it is considered a minimally absorbed chemical.Entities:
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Year: 1984 PMID： 6520886 DOI： 10.1080/15287398409530624
Source DB: PubMed Journal: J Toxicol Environ Health ISSN： 0098-4108