| Literature DB >> 6520830 |
P M Brooks, J O Miners, K Smith, M D Smith, I Fearnley, D J Birkett.
Abstract
Plasma concentrations were measured in 10 patients with rheumatoid arthritis taking 250 mg, 500 mg and 750 mg of D-penicillamine daily. A disproportionate rise in the dose adjusted area under the plasma concentration vs time curve suggested dose dependent kinetics for D-penicillamine. Marked interindividual variability was seen with pharmacokinetic parameters and no correlations were observed between side effects or response and plasma concentrations of reduced D-penicillamine.Entities:
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Year: 1984 PMID： 6520830
Source DB: PubMed Journal: J Rheumatol ISSN： 0315-162X Impact factor: 4.666