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Literature DB >> 65198

Concentration of thyroxine-binding globulin: value of direct assay.

W A Burr, D B Ramsden, S E Evans, T Hogan, R Hoffenberg.

Abstract

The concentration of thyroxine-binding globulin (TBG) in the serum can now be measured by direct assays that are simple and inexpensive. Comparison of a direct measurement of TBG concentration with a widely used indirect method (Thyopac-3) showed that the indirect method was inaccurate when TBG concentrations were high. This will result in an increase in the derived free thyroxine index (FTI), so that euthyroid patients with a raised TBG concentration may be at risk of being labelled thyrotoxic. Correction of serum total thyroxine (T4) concentration according to the actual TBG concentration (T4:TBG ratio) provided a better correlation with thyroid state than FTI.

Entities: Chemical Gene Species

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Year: 1977 PMID： 65198 PMCID： PMC1605130 DOI： 10.1136/bmj.1.6059.485

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

21 in total

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Authors: F CLARK; D B HORN
Journal: J Clin Endocrinol Metab Date: 1965-01 Impact factor: 5.958

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Authors: J ROBBINS
Journal: Arch Biochem Biophys Date: 1956-08 Impact factor: 4.013

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Authors: J E Jones; U S Seal
Journal: J Clin Endocrinol Metab Date: 1967-11 Impact factor: 5.958

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Authors: A W Goolden; J M Gartside; C Sanderson
Journal: Lancet Date: 1967-01-07 Impact factor: 79.321

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Authors: W A Ratcliffe; J G Ratcliffe; A D McBride; W A Harland; T W Randall
Journal: Clin Endocrinol (Oxf) Date: 1974-10 Impact factor: 3.478

6. Indices of thyroid function in thyrotoxicosis.

Authors: R F Harvey
Journal: Lancet Date: 1971-07-31 Impact factor: 79.321

Review 7. Role of plasma proteins in the binding, distribution and metabolism of the thyroid hormones.

Authors: J H Oppenheimer
Journal: N Engl J Med Date: 1968-05-23 Impact factor: 91.245

8. Clinical application of serum-total-thyroxine estimation, resin uptake, and free-thyroxine index.

Authors: P J Howorth; N F Maclagan
Journal: Lancet Date: 1969-02-01 Impact factor: 79.321

9. Thyroxine transport in thyrotoxicosis and hypothyroidism.

Authors: M Inada; K Sterling
Journal: J Clin Invest Date: 1967-09 Impact factor: 14.808

10. Comparison of thyroid function in each trimester of pregnancy with the use of triiodothyronine uptake, thyroxine iodine, free thyroxine, and free thyroxine index.

Authors: J A Souma; D C Niejadlik; S Cottrell; S Rankel
Journal: Am J Obstet Gynecol Date: 1973-08-01 Impact factor: 8.661

8 in total

7. Thyroid function and plasma immunoglobulins in subjects with Down's syndrome (DS) during ontogenesis and zinc therapy.

Authors: M Sustrová; V Strbák
Journal: J Endocrinol Invest Date: 1994-06 Impact factor: 4.256

8. Impact of iodine deficiency on thyroid function in pregnant African women - A possible factor in the genesis of 'small for dates' babies.

Authors: Santosh C Das; Uche P Isichei; Aminu Z Mohammed; Abraham A Otokwula; Abiodun Emokpae
Journal: Indian J Clin Biochem Date: 2005-07