Literature DB >> 6519680

Identical specificity of lupus antibodies and antibodies elicited in rabbits against Sm and RNP antigens.

M Ishaq, R Ali.   

Abstract

Rabbits immunized with purified Sm and RNP small nuclear ribonucleoproteins (snRNPs) produced precipitating and hemagglutinating antibodies against these antigens. These antibodies had immunological specificity identical to the naturally occurring SLE anti-Sm/RNP antibodies as demonstrated by immunoprecipitation results and studies involving the characterization of immunoaffinity purified antigens isolated from the rabbit immune and SLE anti-Sm/RNP IgG affinity columns.

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Year:  1984        PMID： 6519680     DOI： 10.3109/08820138409033891

Source DB:  PubMed          Journal:  Immunol Commun        ISSN： 0090-0877


  3 in total

1.  Immunological characterization of small nuclear ribonucleoproteins reactive with sera of patients with systemic lupus erythematosus.

Authors:  M Ishaq; R Ali
Journal:  J Clin Immunol       Date:  1987-09       Impact factor: 8.317

2.  Polynucleotide specificity of anti-reactive oxygen species (ROS) DNA antibodies.

Authors:  J Ara; R Ali
Journal:  Clin Exp Immunol       Date:  1993-10       Impact factor: 4.330

3.  Immunization of mice with purified U1 small nuclear ribonucleoprotein (RNP) induces a pattern of antibody specificities characteristic of the anti-Sm and anti-RNP autoimmune response of patients with lupus erythematosus, as measured by monoclonal antibodies.

Authors:  R Reuter; R Lührmann
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205
  3 in total

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