Literature DB >> 6518834

On-line pharmacokinetics of chloramphenicol in rat cortex by in vivo electrochemical detection.

A Meulemans, D Henzel, M Brun-Pacaud, J Mohler, P Vicart, P T Huy.   

Abstract

In vivo electrochemical detection of chloramphenicol in rat cortex was investigated with microelectrodes after intravenous injection of chloramphenicol succinate (170 mg X kg-1). A classical pharmacokinetic study with high-performance liquid chromatography (HPLC) determination of chloramphenicol was performed. The two methods gave the same result when chloramphenicol and chloramphenicol succinate were added for the HPLC assay and compared with the voltametric assay. Clinical applications of this new method are suggested.

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Year:  1984        PMID： 6518834     DOI： 10.1159/000238293

Source DB:  PubMed          Journal:  Chemotherapy        ISSN： 0009-3157            Impact factor:   2.544


  4 in total

1.  A model of cefoperazone tissue penetration: diffusion coefficient and protein binding.

Authors:  A Meulemans
Journal:  Antimicrob Agents Chemother       Date:  1992-02       Impact factor: 5.191

2.  Measurement and clinical and pharmacokinetic implications of diffusion coefficients of antibiotics in tissues.

Authors:  A Meulemans; F Paycha; P Hannoun; M Vulpillat
Journal:  Antimicrob Agents Chemother       Date:  1989-08       Impact factor: 5.191

3.  Continuous sampling for determination of pharmacokinetics in rat cerebrospinal fluid.

Authors:  A Meulemans; P Vicart; J Mohler; M Vulpillat; J J Pocidalo
Journal:  Antimicrob Agents Chemother       Date:  1986-12       Impact factor: 5.191

4.  Rifampin concentrations in various compartments of the human brain: a novel method for determining drug levels in the cerebral extracellular space.

Authors:  T Mindermann; W Zimmerli; O Gratzl
Journal:  Antimicrob Agents Chemother       Date:  1998-10       Impact factor: 5.191
  4 in total

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