Literature DB >> 6518275

Delayed aggregation of proteoglycans in adult human articular cartilage.

M T Bayliss, G D Ridgway, S Y Ali.   

Abstract

The biosynthesis and macromolecular organization of proteoglycans was studied in explants of adult human articular cartilage. In a series of pulse-chase experiments, labelling with (35S)sulphate, it was shown that the proteoglycan monomer is synthesized as a precursor that has a low affinity for hyaluronic acid. These findings suggest a possible mechanism by which the rate of incorporation of proteoglycans into the extracellular matrix may be controlled.

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Year:  1984        PMID： 6518275     DOI： 10.1007/bf01138164

Source DB:  PubMed          Journal:  Biosci Rep        ISSN： 0144-8463            Impact factor:   3.840


  12 in total

1.  Synthesis and extracellular assembly of proteoglycans in human articular cartilage.

Authors:  M T Bayliss
Journal:  Agents Actions       Date:  1988-02

2.  The identification and characterization of two populations of aggregating proteoglycans of high buoyant density isolated from post-natal human articular cartilages of different ages.

Authors:  C Webber; T T Glant; P J Roughley; A R Poole
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

3.  Dermatan sulphate proteoglycan from human articular cartilage. Variation in its content with age and its structural comparison with a small chondroitin sulphate proteoglycan from pig laryngeal cartilage.

Authors:  L de O Sampaio; M T Bayliss; T E Hardingham; H Muir
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

4.  Characterization of proteoglycans isolated from associative extracts of human articular cartilage.

Authors:  V Vilím; A J Fosang
Journal:  Biochem J       Date:  1993-07-01       Impact factor: 3.857

5.  Acquisition of hyaluronate-binding affinity in vivo by newly synthesized cartilage proteoglycans.

Authors:  J D Sandy; J R O'Neill; L C Ratzlaff
Journal:  Biochem J       Date:  1989-03-15       Impact factor: 3.857

6.  Structural and biochemical abnormalities of articular cartilage in rheumatoid arthritis.

Authors:  D R Mitrovic; N Darmon
Journal:  Rheumatol Int       Date:  1990       Impact factor: 2.631

7.  Effects of tissue compression on the hyaluronate-binding properties of newly synthesized proteoglycans in cartilage explants.

Authors:  R L Sah; A J Grodzinsky; A H Plaas; J D Sandy
Journal:  Biochem J       Date:  1990-05-01       Impact factor: 3.857

8.  Absence of keratan sulphate from skeletal tissues of mouse and rat.

Authors:  G Venn; R M Mason
Journal:  Biochem J       Date:  1985-06-01       Impact factor: 3.857

9.  Age-related changes in the synthesis of link protein and aggrecan in human articular cartilage: implications for aggregate stability.

Authors:  M C Bolton; J Dudhia; M T Bayliss
Journal:  Biochem J       Date:  1999-01-01       Impact factor: 3.857

10.  Proteoglycans isolated from dissociative extracts of differently aged human articular cartilage: characterization of naturally occurring hyaluronan-binding fragments of aggrecan.

Authors:  V Vilim; A J Fosang
Journal:  Biochem J       Date:  1994-12-15       Impact factor: 3.857
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