Literature DB >> 6517934

2',5'-Oligoadenylate and 2',5'-oligoadenylate phosphodiesterase in human plasma.

H Sawai, K Ishibashi, M Itoh, S Watanabe.   

Abstract

2',5'-Oligoadenylate and 2',5'-oligoadenylate phosphodiesterase activity were detected in the human plasma and serum by sensitive radioimmuno assays. The phosphodiesterase in the serum degraded 20 nM of added 2',5'-oligoadenylate in less than 1 hr. Addition of EDTA in the blood sample inhibited the phosphodiesterase activity completely and allowed the measurement of low levels of 2',5'-oligoadenylate. The concentration in the plasma from healty people was in the range of 0.03 to 0.3 nM.

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Year:  1984        PMID： 6517934     DOI： 10.1016/0006-291x(84)91391-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

1.  Serum 2'-5'oligoadenylate synthetase as a monitoring marker of anti-viral effect during interferon therapy for chronic type B hepatitis.

Authors:  Y Karino; T Sugawara; A Saga; J Yoshida; T Matsushima; T Miyazaki; J Toyota; Y Okuuchi
Journal:  Gastroenterol Jpn       Date:  1989-04

2.  Detection of elevated levels of 2-5A synthetase in serum from children with various infectious diseases.

Authors:  H Sugino; I Mitani; M Koike; T Kodama; J Sokawa; H Sawai; K Ishibashi; M Itoh; S Watanabe; Y Sokawa
Journal:  J Clin Microbiol       Date:  1986-09       Impact factor: 5.948

3.  Accumulation of 2',5'-oligoadenylates in encephalomyocarditis virus-infected mice.

Authors:  W G Hearl; M I Johnston
Journal:  J Virol       Date:  1987-05       Impact factor: 5.103

4.  Clinical significance of serum 2,5-oligoadenylate synthetase and soluble interleukin-2 receptor in hemophiliacs positive and negative for human immunodeficiency virus type 1.

Authors:  J Matsuda; M Gotoh; K Gohchi; M Tsukamoto; N Saitoh; T Kinoshita
Journal:  Clin Diagn Lab Immunol       Date:  1994-03
  4 in total

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