Literature DB >> 6517930

Quantitative study of aluminum binding to human serum albumin and transferrin by a chelex competitive binding assay.

R L Bertholf, M R Wills, J Savory.   

Abstract

Binding of aluminum to human serum albumin and transferrin was investigated using a competitive binding assay incorporating a cation exchange resin, chelex. Both albumin and transferrin were found to produce linear Scatchard plots of aluminum binding data over the aluminum and protein concentration ranges found in humans. Binding constants measured for albumin and transferrin were 1.96 and 0.515 microM, respectively.

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Year:  1984        PMID： 6517930     DOI： 10.1016/0006-291x(84)91385-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  5 in total

1.  Voltage gating in VDAC is markedly inhibited by micromolar quantities of aluminum.

Authors:  E T Dill; M J Holden; M Colombini
Journal:  J Membr Biol       Date:  1987       Impact factor: 1.843

2.  The characterization of aluminium--alanine complex.

Authors:  K S Rao; G V Rao
Journal:  Mol Cell Biochem       Date:  1994-08-17       Impact factor: 3.396

3.  Aluminium transport in blood serum. Binding of aluminium by human transferrin in the presence of human albumin and citrate.

Authors:  S J Fatemi; F H Kadir; G R Moore
Journal:  Biochem J       Date:  1991-12-01       Impact factor: 3.857

4.  Aluminum inhibits erythropoiesis in vitro.

Authors:  J Mladenovic
Journal:  J Clin Invest       Date:  1988-06       Impact factor: 14.808

Review 5.  The biological speciation and toxicokinetics of aluminum.

Authors:  E DeVoto; R A Yokel
Journal:  Environ Health Perspect       Date:  1994-11       Impact factor: 9.031
  5 in total

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