| Literature DB >> 6514829 |
A Inokuchi, Y Oomura, H Nishimura.
Abstract
Administration of pancreatic glucagon into 3rd cerebral ventricle of rats suppressed feeding with potency greater than 1000 times that of peripheral administration. A low dose of glucagon (5 ng) suppressed food intake mainly in short-term and slightly in long-term. A medium dose (25 ng) produced delayed feeding suppression. A high dose (100 ng) suppressed only short-term food intake. From this evidence, it is concluded that intracerebroventricular administration of physiological concentration of pancreatic glucagon suppresses short-term food intake through the hypothalamus. The possible mechanism of feeding suppression by glucagon is discussed.Entities:
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Year: 1984 PMID： 6514829 DOI： 10.1016/0031-9384(84)90160-4
Source DB: PubMed Journal: Physiol Behav ISSN： 0031-9384