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Literature DB >> 6514017

Saturable uptake of [3H]-tryptamine in rabbit platelets is inhibited by 5-hydroxytryptamine uptake blockers.

Abstract

[3H]-tryptamine is taken up by rabbit platelets through an active and saturable process which is temperature sensitive, sodium-dependent and inhibited by imipramine and non-tricyclic 5-hydroxytryptamine (5-HT) uptake blockers. There is an excellent correlation between the Ki for the inhibition of [3H]-tryptamine and [3H]-5-HT uptake in rabbit platelets for a series of 5-HT uptake blockers. These results indicate that [3H]-tryptamine is actively transported through the membrane of blood platelets by the same carrier that transports 5-HT.

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Year: 1984 PMID： 6514017 DOI： 10.1007/bf00496102

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

11 in total

1. Structure activity relations for the inhibition of 5-HT uptake into rat hypothalamic homogenates by serotonin and tryptamine analogues.

Authors: A S Horn
Journal: J Neurochem Date: 1973-10 Impact factor: 5.372

2. [3H]Tryptamine: high affinity binding sites in rat brain.

Authors: K J Kellar; C S Cascio
Journal: Eur J Pharmacol Date: 1982-03-26 Impact factor: 4.432

3. Complex inhibition of [3H]imipramine binding by serotonin and nontricyclic serotonin uptake blockers.

Authors: M Sette; M S Briley; S Z Langer
Journal: J Neurochem Date: 1983-03 Impact factor: 5.372

4. Serotonin modulates the dissociation of [3H]imipramine from human platelet recognition sites.

Authors: L P Wennogle; L R Meyerson
Journal: Eur J Pharmacol Date: 1982-12-24 Impact factor: 4.432

5. Structural requirements for uptake into serotoninergic neurones.

Authors: S B Ross; A L Ask
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1980-04

6. Tetrahydro-beta-carbolines and corresponding tryptamines: In vitro inhibition of serotonin and dopamine uptake by human blood platelets.

Authors: M M Airaksinen; H Svensk; J Tuomisto; H Komulainen
Journal: Acta Pharmacol Toxicol (Copenh) Date: 1980-04

7. Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.

Authors: G V Born; K Juengjaroen; F Michal
Journal: Br J Pharmacol Date: 1972-01 Impact factor: 8.739

8. Tryptamine: a neuromodulator or neurotransmitter in mammalian brain?

Authors: R S Jones
Journal: Prog Neurobiol Date: 1982 Impact factor: 11.685

9. 3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers.

Authors: R Raisman; M S Briley; F Bouchami; D Sechter; E Zarifian; S Z Langer
Journal: Psychopharmacology (Berl) Date: 1982 Impact factor: 4.530

Review 10. Binding of [3H]imipramine and [3H]desipramine as biochemical tools for studies in depression.

Authors: S Z Langer; R Raisman
Journal: Neuropharmacology Date: 1983-03 Impact factor: 5.250

7 in total

1. Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter.

Authors: R Wölfel; K H Graefe
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1992-02 Impact factor: 3.000

Saturable uptake of [3H]-tryptamine in rabbit platelets is inhibited by 5-hydroxytryptamine uptake blockers.

1. Structure activity relations for the inhibition of 5-HT uptake into rat hypothalamic homogenates by serotonin and tryptamine analogues.

2. [3H]Tryptamine: high affinity binding sites in rat brain.

3. Complex inhibition of [3H]imipramine binding by serotonin and nontricyclic serotonin uptake blockers.

4. Serotonin modulates the dissociation of [3H]imipramine from human platelet recognition sites.

5. Structural requirements for uptake into serotoninergic neurones.

6. Tetrahydro-beta-carbolines and corresponding tryptamines: In vitro inhibition of serotonin and dopamine uptake by human blood platelets.

7. Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.

8. Tryptamine: a neuromodulator or neurotransmitter in mammalian brain?

9. 3H-imipramine binding and serotonin uptake in platelets from untreated depressed patients and control volunteers.

Review 10. Binding of [3H]imipramine and [3H]desipramine as biochemical tools for studies in depression.

1. Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter.

Review 2. Studies on the serotonin transporter in platelets.

3. [3H]-5-methoxytryptoline is not actively accumulated by rabbit platelets.

4. A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization.

Review 5. Tryptamine: a metabolite of tryptophan implicated in various neuropsychiatric disorders.

6. Effects of tryptamine mediated through 2 states of the 5-HT2 receptor in calf coronary artery.

7. On the 5-hydroxytryptamine transport across the plasma membrane of rabbit platelets and its inhibition by imipramine.