Literature DB >> 6512831

An epidemiological and genetic study of facial clefting in France. II Segregation analysis.

F Demenais, C Bonaïti-Pellié, M L Briard, J Feingold.   

Abstract

Familial transmission of cleft lip with or without cleft palate (CL(P] and isolated cleft palate (CP) was studied in two French samples of 458 CL(P) and 156 CP nuclear families, using the recently implemented unified model. In neither case could discrimination be achieved between polygenic inheritance and monogenic inheritance with a high proportion of sporadic cases. In this type of disorder with a complex genetic basis the information furnished by such an approach, which only considers the affected status, is discussed. Future investigations on the joint familial transmission of the disease and different marker systems may help to identify the genes involved in these developmental anomalies.

Mesh：

Year:  1984        PMID： 6512831      PMCID： PMC1049343          DOI： 10.1136/jmg.21.6.436

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  20 in total

1.  A genetic study of facial clefting in Northern England.

Authors:  J C Bear
Journal:  Clin Genet       Date:  1976-03       Impact factor: 4.438

2.  Facial clefting: an alternative biologic explanation for its complex etiology.

Authors:  M Melnick; E D Shields; D Bixler; P M Conneally
Journal:  Birth Defects Orig Artic Ser       Date:  1977

3.  A genetic study of cleft lip and palate in Hawaii. II. Complex segregation analysis and genetic risks.

Authors:  C S Chung; G H Ching; N E Morton
Journal:  Am J Hum Genet       Date:  1974-03       Impact factor: 11.025

4.  Analysis of family resemblance. 3. Complex segregation of quantitative traits.

Authors:  N E Morton; C J MacLean
Journal:  Am J Hum Genet       Date:  1974-07       Impact factor: 11.025

Review 5.  The genetics of cleft lip and cleft palate.

Authors:  F C Fraser
Journal:  Am J Hum Genet       Date:  1970-05       Impact factor: 11.025

6.  A family study on cleft lip with or without cleft palate and posterior cleft palate in Hungary.

Authors:  A Czeizel; G Tusnady
Journal:  Hum Hered       Date:  1972       Impact factor: 0.444

7.  Incidence of cleft lip and palate in the offspring of cleft parents.

Authors:  D Bixler; P Fogh-Andersen; P M Conneally
Journal:  Clin Genet       Date:  1971       Impact factor: 4.438

8.  Complex segregation analysis.

Authors:  N E Morton; S Yee; R Lew
Journal:  Am J Hum Genet       Date:  1971-11       Impact factor: 11.025

9.  Further analysis of familial transmission of congenital glaucoma.

Authors:  F Demenais
Journal:  Am J Hum Genet       Date:  1983-11       Impact factor: 11.025

10.  Allelic restriction: a biologic alternative to multifactorial threshold inheritance.

Authors:  M Melnick; E D Shields
Journal:  Lancet       Date:  1976-01-24       Impact factor: 79.321
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  4 in total

Review 1.  [Cheilognathopalatoschisis: its classification and epidemiology].

Authors:  U Hillig
Journal:  Fortschr Kieferorthop       Date:  1991-08

2.  Segregation analysis of cleft lip with or without cleft palate: a comparison of Danish and Japanese data.

Authors:  C S Chung; D Bixler; T Watanabe; H Koguchi; P Fogh-Andersen
Journal:  Am J Hum Genet       Date:  1986-11       Impact factor: 11.025

3.  Cleft lip with or without cleft palate in Shanghai, China: evidence for an autosomal major locus.

Authors:  M L Marazita; D N Hu; M A Spence; Y E Liu; M Melnick
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025

4.  Cleft lip and palate in southwestern Iran: an epidemiologic study of live births.

Authors:  Mohammad Hossain Rajabian; Shahin Aghaei
Journal:  Ann Saudi Med       Date:  2005 Sep-Oct       Impact factor: 1.526
  4 in total

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