| Literature DB >> 6512268 |
R Lindskov, H C Wulf, G L Wantzin, E Niebuhr.
Abstract
Sister chromatid exchange (SCE), which is considered a sensitive method in evaluation of mutagenicity and may be an indicator of carcinogenicity, was determined in lymphocytes from 8 patients with severe psoriasis who underwent treatment with oral methotrexate (MTX). During the treatment period (median 118 days, range 50-298 days) a significant increase in SCE compared to the pretreatment value was found in 1 patient only. It is concluded that no long-term damage as measured by SCE occurs in lymphocytes from psoriasis patients treated with MTX.Entities:
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Year: 1984 PMID： 6512268 DOI： 10.1111/1523-1747.ep12260950
Source DB: PubMed Journal: J Invest Dermatol ISSN： 0022-202X Impact factor: 8.551