Literature DB >> 65119

Persistent SV5 virus infection in continuous cell cultures.

L Y Zakstelskaya, V M Zhdanov, M A Yakhno, B V Gushchin, S M Klimenko, S A Demidova, N G Konovalova, E A Gushchina.   

Abstract

A continuous line of guinea pig kidney cells (CGPK/H) and a continuous line of mouse fibroblasts (L/H) spontaneously infected with parainfluenza virus SV5 were found. These cultures showed no enhanced cell degeneration or symplast formation, nor was haemagglutinin accumulation or infectious virus demonstrated in them. However, regular reproduction of ribonucleoprotein (RNP) characteristic of parainfluenza viruses, morphologically complete virions and antigens producing antibody to SV5 virus were found in the cells. Focal haemadsorption neutralized by antiserum to SV5 virus was also demonstrated. The infection persisted in the cell populations for over 2 years (the observation period) under standard conditions of cell dispersion and subcultivation.

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Year:  1976        PMID： 65119

Source DB:  PubMed          Journal:  Acta Virol        ISSN： 0001-723X            Impact factor:   1.162


  6 in total

1.  Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge.

Authors:  S Mark Tompkins; Yuan Lin; George P Leser; Kari A Kramer; Debra L Haas; Elizabeth W Howerth; Jie Xu; Mary J Kennett; Russell K Durbin; Joan E Durbin; Ralph Tripp; Robert A Lamb; Biao He
Journal:  Virology       Date:  2007-01-23       Impact factor: 3.616

2.  Evolution of in vitro persistence of two strains of canine parainfluenza virus. Brief report.

Authors:  W Baumgärtner; S Krakowka; J Blakeslee
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

3.  Recombinant parainfluenza virus 5 expressing hemagglutinin of influenza A virus H5N1 protected mice against lethal highly pathogenic avian influenza virus H5N1 challenge.

Authors:  Zhuo Li; Alaina J Mooney; Jon D Gabbard; Xiudan Gao; Pei Xu; Ryan J Place; Robert J Hogan; S Mark Tompkins; Biao He
Journal:  J Virol       Date:  2012-10-17       Impact factor: 5.103

4.  The switch between acute and persistent paramyxovirus infection caused by single amino acid substitutions in the RNA polymerase P subunit.

Authors:  Dan F Young; Elizabeth B Wignall-Fleming; David C Busse; Matthew J Pickin; Jack Hankinson; Elizabeth M Randall; Amy Tavendale; Andrew J Davison; Douglas Lamont; John S Tregoning; Steve Goodbourn; Richard E Randall
Journal:  PLoS Pathog       Date:  2019-02-11       Impact factor: 6.823

5.  Evaluating a parainfluenza virus 5-based vaccine in a host with pre-existing immunity against parainfluenza virus 5.

Authors:  Zhenhai Chen; Pei Xu; Gregory W Salyards; Stephen B Harvey; Balazs Rada; Zhen F Fu; Biao He
Journal:  PLoS One       Date:  2012-11-20       Impact factor: 3.240

6.  Parainfluenza Virus 5 Infection in Neurological Disease and Encephalitis of Cattle.

Authors:  Melanie M Hierweger; Simea Werder; Torsten Seuberlich
Journal:  Int J Mol Sci       Date:  2020-01-13       Impact factor: 5.923
  6 in total

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