Literature DB >> 6511850

Improved gas-liquid chromatographic method for the determination of baclofen in plasma and urine.

G Kochak, F Honc.   

Abstract

A simple, rapid and sensitive assay for baclofen analysis has been developed. Baclofen and the internal standard are analyzed by gas-liquid chromatography with electron-capture detection after esterification of the carboxyl group to the butyl ester and acylation of the amino group to the pentafluoropropionylamide. Recovery from biological matrixes is accomplished by ion-pair extraction. The limit of quantitation of the entire assay as stated is about 10 ng/ml baclofen in plasma.

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Year:  1984        PMID： 6511850     DOI： 10.1016/0378-4347(84)80096-1

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

Review 1.  Spasticity and drug therapy.

Authors:  E W Wuis
Journal:  Pharm Weekbl Sci       Date:  1987-10-16

2.  Application of high-resolution mass spectrometry to determination of baclofen in a case of fatal intoxication.

Authors:  Paweł Szpot; Agnieszka Chłopaś; Grzegorz Buszewicz; Grzegorz Teresiński
Journal:  Forensic Toxicol       Date:  2016-03-29       Impact factor: 4.096

3.  Validated Method for the Quantification of Baclofen in Human Plasma Using Solid-Phase Extraction and Liquid Chromatography-Tandem Mass Spectrometry.

Authors:  Limon Khatun Nahar; Rosa Elena Cordero; David Nutt; Anne Lingford-Hughes; Samuel Turton; Claire Durant; Sue Wilson; Sue Paterson
Journal:  J Anal Toxicol       Date:  2015-11-04       Impact factor: 3.367

4.  Simultaneous Quantitation of S(+)- and R(-)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC-APCI-MS/MS: An Application for Clinical Studies.

Authors:  Qingfeng He; Yashpal S Chhonker; Matthew J McLaughlin; Daryl J Murry
Journal:  Molecules       Date:  2020-01-08       Impact factor: 4.411
  4 in total

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